Dalal Al-Rubaye1*, Talib Saleh Al-Rubaye1, Marwa Shaker1 and Hassan M Naif2

 1Department of Biotechnology, College of Science, University of Baghdad, Iraq

2Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, PO Box 64030 Baghdad,  Iraq

*Corresponding author: dr.tbdalal@gmail.com

Received:  June 7, 2022/ Revised: June 22, 2022 / Accepted: June 26, 2022

Abstract

Crimean-Congo haemorrhagic fever (CCHF) is an emerging zoonotic disease defined as a disease that passes from an animal or insect to a human. It is responsible for several deaths in humans, while the hosts, like cows, sheep, and goats are not affected. The CCHF was recognized for the first time in Iraq in 1979 where the virus was isolated from human cases and characterized.  Since then, several small-scale outbreaks have been reported in 2019, 2021, and 2022. During this period, awareness workshops were conducted targeting government officials, veterinarians, medical doctors, and assistant staff. A strong collaboration strategy was put into place between these sectors together with the united nation office in Baghdad. These resulted in accelerating of the implementation of the amendment of the Veterinary Medical Progression Law 2021, establishing a supreme Committee for Epidemiological Disease Control supervised by the Council of Ministers and forming a collaboration crisis cell from Baghdad and other municipalities and ministries concerned, and placed detailed safety, one health and control measures for all parties involved. The current outbreak cases reached 90 cases with 18 deaths with the majority being in Thi-Qar Governorate. The current situation is difficult to deal with such a highly virulent virus due to the unavailability of an effective vaccine nor BSL-4 facility to safely deal/handle the virus in the country.

Keywords  Arbovirus, Hemorrhagic fever, Tickborn viruses, Livestock, Iraq

How to cite this article

Al-Rubaye, D., Al-Rubaye, T.S., Shaker, M. and Naif, H.M. (2022). Recent outbreaks of crimean–congo hemorrhagic fever (CCHF) in Iraq.  Science Archives Vol. 3 (2), 109–112. http://dx.doi.org/10.47587/SA.2022.3205

References

Appannanavar, S. B., & Mishra, B. (2011). An update on Crimean Congo hemorrhagic fever. Journal of global infectious diseases3(3), 285.

Aslam, S., Latif, M. S., Daud, M., Rahman, Z. U., Tabassum, B., Riaz, M. S., … & Husnain, T. (2016). Crimean‑Congo hemorrhagic fever: Risk factors and control measures for the infection abatement. Biomedical reports4(1), 15-20.

Carroll, S. A., Bird, B. H., Rollin, P. E., & Nichol, S. T. (2010). Ancient common ancestry of Crimean-Congo hemorrhagic fever virus. Molecular phylogenetics and evolution55(3), 1103-1110.

Carter, S. D., Surtees, R., Walter, C. T., Ariza, A., Bergeron, É., Nichol, S. T., … & Barr, J. N. (2012). Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein. Journal of virology86(20), 10914-10923.

Centers for Disease Control and Prevention (CDC): Update: Management of patients with suspected viral hemorrhagic fever – United States. MMWR Morb Mortal Wkly Rep. 44:475–479. 1995.

Epidemic and pandemic-prone diseases, WHO builds capacity of rapid response team in Iraq with a focus on Crimean-Congo haemorrhagic fever (a three-day workshop, Baghdad, Iraq, 22 March 2022).

Ergönül, Ö. (2006). Crimean-Congo haemorrhagic fever. The Lancet infectious diseases6(4), 203-214.

Gordon, S. W., Linthicum, K. J., & Moulton, J. R. (1993). Transmission of Crimean-Congo hemorrhagic fever virus in two species of Hyalomma ticks from infected adults to cofeeding immature forms. Am J Trop Med Hyg. 48(4), 576-580.

Hamidinejad, M. A., Ghaleh, H. E. G., Farzanehpour, M., Bolandian, M., & Dorostkar, R. (2021). Crimean-Congo hemorrhagic fever from the immunopathogenesis, clinical, diagnostic, and therapeutic perspective: A scoping review. Asian Pacific Journal of Tropical Medicine14(6), 254-265.

Leblebicioglu, H., Bodur, H., Dokuzoguz, B., Elaldi, N., Guner, R., Koksal, I., … & Senturk, G. C. (2012). Case management and supportive treatment for patients with Crimean-Congo hemorrhagic fever. Vector-Borne and Zoonotic Diseases12(9), 805-811.

Lloyd, E. and Perry, H.: Infection control for viral haemorrhagic fevers in the African health care setting. Centers for Disease Control and Prevention and World Health Organization, Infection Control for Viral Haemorrhagic Fevers in the African Health Care Setting. (Atlanta). Centers for Disease Control and Prevention. 1–198. 1998.\

Mazzola, L. T., & Kelly-Cirino, C. (2019). Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease. BMJ global health4(Suppl 2), e001114.

Nuttall, P. A., & Labuda, M. (2003). Dynamics of infection in tick vectors and at the tick-host interface. Adv Virus Res60, 233-272.

Nuttall, P. A., & Labuda, M. (2004). Tick–host interactions: saliva-activated transmission. Parasitology129(S1), S177-S189.

Shayan, S., Bokaean, M., Shahrivar, M. R., & Chinikar, S. (2015). Crimean-Congo hemorrhagic fever. Laboratory medicine46(3), 180-189.

Shepherd, A. J., Swanepoel, R., Leman, P. A., & Shepherd, S. P. (1987). Field and laboratory investigation of Crimean-Congo haemorrhagic fever virus (Nairovirus, family Bunyaviridae) infection in birds. Transactions of the Royal Society of Tropical Medicine and Hygiene81(6), 1004-1007.

Virus Taxonomy: 2018 Release, EC 50, Washington, DC, July 2018, Email ratification October 2018 (MSL #33) https://talk.ictvonline.org/taxonomy.

Whitehouse, C. A. (2004). Crimean–Congo hemorrhagic fever. Antiviral research64(3), 145-160.

WHO: Crimean Congo haemorrhagic fever. Fact Sheet No. 208. January; 2013.http://www.who.int/mediacentre/factsheets/fs208/en/Accessed. March. 2015.

Wilson, M. L., Gonzalez, J. P., Cornet, J. P., & Camicas, J. L. (1991). Transmission of Crimean-Congo haemorrhagic fever virus from experimentally infected sheep to Hyalomma truncatum ticks. Research in Virology142(5), 395-404.

Zivcec, M., Safronetz, D., Scott, D. P., Robertson, S., & Feldmann, H. (2018). Nucleocapsid protein-based vaccine provides protection in mice against lethal Crimean-Congo hemorrhagic fever virus challenge. PLoS neglected tropical diseases12(7), e0006628.

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