Orugun Folake Toluwalope1, Ogbu George Idikwu2, Stephen Ajen Anzaku3

1Department Obstetrics and Gynaecology, Federal Medical Centre, Keffi, Nigeria

2Department of Obstetrics and Gynaecology, Federal Medical Centre, Keffi, Nigeria

3Department of Obstetrics & Gynaecology, College of Medicine & Health Sciences, Bingham University, Karu, Jos Campus/Bingham University Teaching Hospital, Jos, Plateau State. Chief Medical Director, Bingham University Teaching Hospital, Jos. Nigeria

Corresponding author: talktoogbu@gmail.com

Received: June 25, 2022 / Revised: July 29, 2022/ Accepted: Aug 3, 2022

Abstract

Hookworm infestation is a major public health problem in developing countries and infestation in patients including pregnant women could result in anaemia and malnutrition. The study aimed to determine infection burden, socio-demographic risk factors, and impacts of hookworm infestation among pregnant women in Federal Medical Centre Keffi. The study was a cross-sectional survey of pregnant women presenting at the booking clinic of the hospital over 3 months. Participants were recruited using a systematic sampling technique. Their biodata and information on socio-demographic risk factors for hookworm infestation were obtained and recorded in a pre-designed proforma. Participants’ clinical details were also assessed. Stool sample from each participant was analyzed for hookworm presence, egg burden, and participants’ Packed Cell Volume was determined. The data was analysed using the Statistical Package for Social Sciences (SPSS) version 22. Categorical variables were compared using Fisher’s exact test while t-test was used for the comparison of continuous variables and Spearman’s Correlation was used to determine the relationship between non-parametric variables. P-value was significant if <0.05 at 95% Confidence Interval. The prevalence of hookworm infestation was 10% while 6% of them were anemic.  There was no statistically significant relationship between hookworm infestation and anaemia (P-value =0.911). Hookworm infestation was associated with place of residence, sewage disposal system, and source of drinking water (P-values of 0.012, 0.001, and 0.002 respectively). Prevalence of hookworm infestation among the antenatal attendees was relatively high but had no association with anaemia.

Keywords Hookworm infestation, malnutrition, anaemia

References

Agan, T. U., Ekabua, J. E., Udoh, A. E., Ekanem, E. I., Efiok, E. E., & Mgbekem, M. A. (2010). Prevalence of anemia in women with asymptomatic malaria parasitemia at first antenatal care visit at the University of Calabar Teaching Hospital, Calabar, Nigeria. International Journal of Women’s Health2, 229.

Alli, J. A., Okonko, I. O., Kolade, A. F., Nwanze, J. C., Dada, V. K., & Ogundele, M. (2011). Prevalence of intestinal nematode infection among pregnant women attending antenatal clinic at the University College Hospital, Ibadan, Nigeria. Advances in Applied Science Research2(4), 1-13.

Baidoo, S. E., Tay, S. C. K., & Abruquah, H. H. (2010). Intestinal helminth infection and anaemia during pregnancy: A community based study in Ghana. African journal of microbiology research4(16), 1713-1718.

Bärenbold, O., Raso, G., Coulibaly, J. T., N’Goran, E. K., Utzinger, J., & Vounatsou, P. (2017). Estimating sensitivity of the Kato-Katz technique for the diagnosis of Schistosoma mansoni and hookworm in relation to infection intensity. PLoS neglected tropical diseases11(10), e0005953.

Bondevik, G. T., Eskeland, B., Ulvik, R. J., Ulstein, M., Lie, R. T., Schneede, J., & Kvåle, G. (2000). Anaemia in pregnancy: possible causes and risk factors in Nepali women. European Journal of Clinical Nutrition54(1), 3-8.

Brooker, S., Hotez, P. J., & Bundy, D. A. (2008). Hookworm-related anaemia among pregnant women: a systematic review. PLoS neglected tropical diseases2(9), e291.

Brooker, S. (2010). Estimating the global distribution and disease burden of intestinal nematode infections: adding up the numbers–a review. International journal for parasitology40(10), 1137-1144.

Bull, B. S., Koepke, J. A., Simson, E., Van Assendelft, O. W. (2000). Procedure for determining packed cell volume by the microhematocrit method; approved standard. 3rd editio. National Committee for Clinical Laboratory Standards, editor. Pennsylvania: National Committee for Clinical Laboratory Standards, 1-18.

De Silva, N. R., Brooker, S., Hotez, P. J., Montresor, A., Engels, D., & Savioli, L. (2003). Soil-transmitted helminth infections: updating the global picture. Trends in parasitology19(12), 547-551.

Feldmeier, H., & Schuster, A. (2012). Mini review: Hookworm-related cutaneous larva migrans. European journal of clinical microbiology & infectious diseases31(6), 915-918.

Government of Nigeria, Ministry of Health, UNICEF Nigeria, Canadian International Development Agency, PATHS, UNFPA, USAID, et al. National Integrated Maternal Newborn and Child Health Strategy [Internet]. Government of Nigeria, Ministry of Health and UNICEF. 2009 [cited 2018 Dec 24]. p. 1–2. Available from: https://www.unicef.org/nigeria/ng_publications_IMNCHbrochure.pdf

Green, K. I., Ojule, J. D. (2015). Helminthiasis in pregnancy in the Niger-Delta Region of Nigeria. Niger Heal J, 15:69–77.

Haider, B. A., Salam, R. A., Humayun, Q., & Bhutta, Z. A. (2015). Effect of administration of antihelminthics for soil‐transmitted helminths during pregnancy. Cochrane Database of Systematic Reviews, (6).

Hotez, P. J., Zhan, B., Bethony, J. M., Loukas, A., Williamson, A., Goud, G. N. & Russell, P. K. (2003). Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative. International journal for parasitology33(11), 1245-1258.

Jourdan, P. M., Lamberton, P. H., Fenwick, A., & Addiss, D. G. (2018). Soil-transmitted helminth infections. The Lancet391(10117), 252-265.

Komolafe, J. O., Kuti, O., Oni, O., & Egbewale, B. E. (2005). Sociodemographic characteristic of anaemic gravidae at booking: A preliminary study liesha, Western Nigeria. Nigerian Journal of Medicine14(2), 151-154.

Mpairwe, H., Tweyongyere, R., & Elliott, A. (2014). Pregnancy and helminth infections. Parasite immunology36(8), 328-337.

Omigbodun, A. O. (2004). Recent trends in the management of anaemia in pregnancy. Trop J Obs Gynaecol, 21:1–3.

U.S. (2014). Department of Health & Human Services. Hookworm [Internet]. Centers for Disease Control and Prevention. [cited 2018 Dec 24]. p. 1–2. Available from: https://www.cdc.gov/parasites/hookworm/gen_info/faqs.html

Wang, H., Naghavi, M., Allen, C., Barber, R. M., Carter, A., Casey, D. C., (2016). Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388: 1459–544.

Weatherhead, J. E., Woc-Colburn, L. E. (2014). Helminth infections in pregnant women. Medscape, 821917: 1–5.

World Health Organization. New guidelines on antenatal care for a positive pregnancy experience [Internet]. World Health Organization; 2017 [cited 2018 Dec 24]. p. 1–4. Available from: http://www.who.int/reproductivehealth/news/antenatal-care/en/

Ziegelbauer, K., Speich, B., Mäusezahl, D., Bos, R., Keiser, J., & Utzinger, J. (2012). Effect of sanitation on soil-transmitted helminth infection: systematic review and meta-analysis. PLoS medicine9(1), e1001162.

How to cite this article                                                                                                                                                              Toluwalope, O. F., Ogbu, G. I., O. G., Anzaku, S. A. (2022). Burden of hookworm infestation and association with socio-demographic and clinical factors in a clinical setting in Nigeria a review. Science Archives, Vol. 3 (3), 168-174. https://doi.org/10.47587/SA.2022.3304

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