Nuha Ali Hadi1, Ayysha Shihab ahmed2, Rabeah.T2, Miam huseein ali1          

1College of Education,  Department of Chemistry, University of Samarra, Iraq

2College of Applied Sciences, Department of Chemistry, University of Samarra, Iraq

(✉) Corresponding Author: Nuhaali921@gmail.com

Received:  July 30, 2022/ Revised: Aug 19, 2022/ Accepted: Aug 23, 2022

Abstract

The present study aimed to find out the effect The study aimed to extract flavonoids and tannin from sumac, myrtle, and on domestic rabbits exposed to nephrotoxicity with gentamicin. the percentage of flavonoids recorded from myrtle and Sumac is 13.8%, and 12.7%, respectively. The percentage of tannin recorded from myrtle and Sumac is 15.9 %, and 12.7%, respectively. The study was conducted inside the body of the organism and nephrotoxicity was developed with gentamicin by injecting animals 80 mg/ml/day (IP) for two weeks, after which I was dosed orally with the Flavonoid extract of sumac and myrtle and tannin extract of sumac and myrtle for a month at a rate of 1 ml/kg/day. A significant increase in the group’s dose was found with gentamicin. An increase of 0.05 compared to the healthy control group. As well as a significant decrease of 0.05 for the groups treated with extracts compared to the control group for urea and creatinine. The total protein showed a significant increase of 0.05 for the group administered with gentamicin compared with the healthy control group and a significant decrease for the groups fed with extracts compared to the control group treated with gentamicin. As for albumin, a significant decrease was recorded for the group treated with gentamicin compared to the healthy control group by 0.05, and a significant increase for the groups treated with plant extracts compared with the control group treated with gentamicin. Uric acid showed a significant decrease in the groups treated with gentamicin compared with the healthy control group.

Keywords: Flavonoids, Tannins, Gentamicin, Biochemicals, Histological Study

References

Abdel-Raheem, I. T., El-Sherbiny, G. A., & Taye, A. (2010). Green tea ameliorates renal oxidative damage induced by gentamicin in rats. Pak J Pharm Sci23(1), 21-28.

Abdullah, L. S., Alloush, Z. A., Al-Jarrah, I. A. (2009). Study of the enzyme metalloendopeptidase and its relationship to chronic renal impairment disease. Al-Rafidain Science Journal. 22(4), pg71.

AlAnbori, D. K., AlNimer, M. S., & AlWeheb, A. M. (2008). Antibacterial activity of ethanolic extract of Myrtus communis. L leaves against salivary Mutans streptococci. Saudi Dental Journal20(2), 82-87.

Al-Hamdani, N. F., Al Falih, T. K., Ahmed, M. (2017). The effect of polyphenol extract of sumac fruits (Rhus coriaria) on body weight, lipid profile and leptin levels in laboratory mice, Department of Chemistry, Al-Rafidain Science Journal.22(4), pg71.

Ali, N. A. M., & Saeed, S. Z. (2012). Nephro-protective effect of Punica granatum in gentamicin-induced nephrotoxicity in rats. Medical Journal of Babylon9(1), 220-8.

Al-Maadid, Amer, M. H. (2014). A taxonomic study of the genus of sumac (Anacardiaceae) Rhus L. Journal of Sciences of Al-Rafidain.17(10), 100-1144).

Al-Majed, A. A., Mostafa, A. M., Al-Rikabi, A. C., & Al-Shabanah, O. A. (2002). Protective effects of oral arabic gum administration on gentamicin-induced nephrotoxicity in rats. Pharmacological Research46(5), 445-451.

Al-Obeidi, W. M. L. (2012). The effect of a number of medicinal plant extracts on the concentration of melatonin and some physiological and histological variables in white male rats. Master Thesis, College of Education-University of Tikrit.

Al-Salami, N. Y. A. (2000). In vivo study of the effect of extracts of Pseudomonas aeruginosa on Allium sativum and garlic communis L. Master Thesis, University of Kufa. p106.

Alwan, B, H., Ismail, S, A., Emadal, H. (2009). Effect of crude extracts of sumac plant) and adhesion of Pseudomonasaeruginosa and E. Coli bacteria, clinically isolated in patients with acute UTI. College of Science, Al-Mustansiriya University. 60, 757-76.

Attia, R., Messaoud, C., Arraki, K., Zedet, A., Demougeot, C., Boussaïd, M., & Girard, C. (2019). Phytochemical screening and arginase inhibitory activity of extracts from several Tunisian medicinal plants. South African Journal of Botany120, 313-318.

Bartošíková, L., Nečas, J., Suchý, V., Kubinova, R., Vesela, D., Beneš, L., & Fráňová, J. (2003). Monitoring of antioxidative effect of morine in alloxan-induced diabetes mellitus in the laboratory rat. Acta Veterinaria Brno72(2), 191-200.

Boden, G., Chen, X., Mozzoli, M., & Ryan, I. (1996). Effect of fasting on serum leptin in normal human subjects. The Journal of Clinical Endocrinology & Metabolism81(9), 3419-3423.

Chttopadhyay, R. R. (1996). Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract. Part IV. Gen Pharmacol27, 431-434.

El Sissi H. I., El Ansary, M. A. I. I. (1967).  Tannins and Poly phenolice of the leaves of myrtys communts Tannins.

Hadi, N. A., & Mahmood, R. T. (2020). A Study of The Effect of Aqueous and Alcoholic Extract of Saliva on The Reduction of Induced Hepatotoxicity in Laboratory Animals with Carbon Tetrachloride CCL4. Systematic Reviews in Pharmacy11(11), 591-595.

Haidari, F., Rashidi, M. R., Keshavarz, S. A., Mahboob, S. A., Eshraghian, M. R., & Shahi, M. M. (2008). Effects of onion on serum uric acid levels and hepatic xanthine dehydrogenase/xanthine oxidase activities in hyperuricemic rats. Pakistan journal of biological sciences: PJBS11(14), 1779-1784.

Islem, Y., Faten, Y., Wafa, G. (2021). Phytochemicals, antioxidant and anit-proliferatier activites of Myrtus communis L.genotypes from Tunisia. South Africa Journal of Botany, 37, p35-45.

Kokate, C. K., Purohit, A. P. and Gokhale, S. B. (1993). “Pharmacognosy”17thED, Nirali Prakashan:p. 99, 231, 185.

Olowokudejo, J. D., Kadiri, A. B., & Travih, V. A. (2008). An ethnobotanical survey of herbal markets and medicinal plants in Lagos State of Nigeria.

Oloyede, O. I. (2009). Chemical profile and antimicrobial activity of Cymbopogon citratus leaves. Journal of Natural Products (India)2, 98-103.

Paiva‐Martins, F., Fernandes, J., Rocha, S., Nascimento, H., Vitorino, R., Amado, F., & Santos‐Silva, A. (2009). Effects of olive oil polyphenols on erythrocyte oxidative damage. Molecular nutrition & food research53(5), 609-616.

Priya, R., Ilavenil, S., Kaleeswaran, B., Srigopalram, S., & Ravikumar, S. (2011). Effect of Lawsonia inermis on tumor expression induced by Dalton’s lymphoma ascites in Swiss albino mice. Saudi journal of biological sciences18(4), 353-359.

Riyam, A. S., Abdul-Karim, S. M. and Samira, A. A. (2020). Protective effect of citrus honey toward the histopathological and biochemical nephrotoxicity damages of gentamicin–induced in local rabbits Oryctolagus cuniculus. Tikrit Journal of Pure Science.Vol. 25(1).

Sakhr, K., & El Khatib, S. (2020). Physiochemical properties and medicinal, nutritional and industrial applications of Lebanese Sumac (Syrian Sumac-Rhus coriaria): A review. Heliyon6(1), e03207.

Shihab, O. H., Ahmed, S. A. (2016).  Aqueous, alcoholic and oil extraction from Sumac plant, a study of its effectiveness against bacteria and cancerous tumors, and a study of complex formation with elements of coumet and cadmium, Al-Rafidain Science Journal. 24(4), pg91.

Sofowara, A. (2006). Medical plants and traditional medicine in Africa. Rep. edition.

Van Loo, P., De Bruyn, A., & Verzele, M. (1988). On the liquid chromatography and identification of the flavonoids, present in the “sumach tannic acid” extracted from Rhus coriaria. Chromatographia25(1), 15-20.

How to cite this article

Hadi, N. A., Ahmed, A. S., Rabeah, T., Ali, M. H. (2022). Estimation of flavonoids and tannins extracted from medicinal plants on gentamicin-induced nephrotoxicity in local Iraqi rabbits. Science Archives, Vol 3(3), 204-210. https://doi.org/10.47587/SA.2022.3309

License                      Article Metadata

This work is licensed under a Creative Commons Attribution 4.0 International License.

[pdf_attachment file="1" name="View Details"]