Chinwe Dolly Udeka1,  Micheal Abimbola Oladosu2*, Moses Adondua Abah3,  Abimbola Mary Oluwajembola4 and  Emmanuel Amuchechukwu Kevin5

 1,2,3,4,5Research Hub Nexus Institute, Lagos, Nigeria.

2,4Department of Chemical Sciences, Faculty of Science, Anchor University, Lagos, Nigeria

Received: May 2, 2026/ Revised: June 2 2026/Accepted: June 8, 2026

Highlights

  • Reviews recent advances in novel drug delivery systems from 2020–2025.
  • Examines nanoparticle-based, lipid-based, and polymeric drug delivery platforms.
  • Highlights smart stimuli-responsive systems for targeted and controlled drug release.
  • Explores AI-driven formulation design and personalized medicine applications.
  • Discusses challenges in scalability, biocompatibility, regulation, and clinical translation.

Abstract

The pharmaceutical industry is experiencing a paradigm shift with the emergence of novel drug delivery systems that address fundamental limitations of conventional therapies. This comprehensive review examines recent advances in drug delivery technologies from 2020 to 2025, focusing on nanoparticle-based systems, smart stimuli-responsive platforms, personalized medicine approaches, and advanced biomaterials. Key innovations include lipid-based nanocarriers, polymeric nanoparticles, intelligent drug delivery systems responding to endogenous and exogenous stimuli, and AI-driven formulation optimization. These technologies demonstrate significant improvements in drug bioavailability, targeted delivery, controlled release kinetics, and reduced systemic toxicity. Current challenges include scalability, regulatory approval pathways, biocompatibility concerns, and translation from bench to bedside. This review provides critical insights into the current state of drug delivery science, highlighting transformative technologies poised to revolutionize therapeutic outcomes while addressing patient compliance and personalized treatment needs.

Keywords: Novel drug delivery systems, nanoparticles, smart delivery, stimuli-responsive, personalised medicine, bioavailability, targeted therapy

How to cite this article

Udeka, C. D., Oladosu, M. A., Abah, M. A., Oluwajembola, A. M., & Kevin, E. A. (2026). Comprehensive review of novel drug delivery systems: Current status and future directions (2025). Science Archives, 7(2), 173–180. https://doi.org/10.47587/SA.2026.7216

This work is licensed under a Creative Commons Attribution 4.0 International License

 

View Details