Sanghamitra Pal and Goutam Paul
Molecular Neurotoxicology Laboratory, Department of Physiology, University of Kalyani, Kalyani, Nadia,
West Bengal, India
*Corresponding author: goutampaul.ku@gmail.com
Received: May 4, 2021 / Revised: June 12, 2021/ Accepted: June 18, 2021
Abstract
Bisphenol S (BPS) is a synthetic chemical that is used as a substitute for toxic Bisphenol A (BPA) for the production of polycarbonate plastics, epoxy resins, and paper products. This study has been undertaken to perform a comparative analysis of the toxicity of BPS and BPA on heart ventricular musculature. Adult male albino rats were given BPS, BPA, and a combination of both BPS and BPA for 30 consecutive days via oral gavage. From the results, it can be observed that both BPS and BPA significantly decreased the activities of different antioxidant enzymes (SOD, CAT, GPx, GR, GST), whereas malondialdehyde level has been significantly increased compared to the control. The inhibition of the activities of antioxidant enzymes is more pronounced in BPA than BPS exposed groups. Moreover, BPA leads to a greater degree of degeneration of heart ventricular musculature than BPS. In conclusion, though BPS induces oxidative stress-mediated damages of heart ventricular musculature, the potency of BPS-induced toxicity is comparatively lower than BPA.
Keywords BPA, BPS, Heart, Oxidative stress
How to cite this article:
Pal, S. and Paul, G. (2021). A comparative study on the toxicity of Bisphenol A (BPA) and Bisphenol S (BPS) on heart ventricular muscle. Science Archives, Vol. 2 (2), 84-89.http://dx.doi.org/10.47587/SA.2021.2204
Copyright
This is an open-access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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