Diptendu Sarkar¹✉
, Atanu Mondal² and Subha Roy²
¹Department of Microbiology, Ramakrishna Mission Vidyamandira, Belur Math, Howrah -711202, West Bengal, India
²Department of Computer Science, Ramakrishna Mission Vidyamandira, Belur Math, Howrah -711202, West Bengal, India
Received: Aug 30, 2022/ Revised: Sept 13, 2022/ Accepted: Sept 24, 2022
(✉) Corresponding Author: diptendu81@gmail.com
Abstract
Simulating the potential anticancer action of medicines from the genus Spatholobus is the aim of the current investigation. The 33 bioactive compounds that make up the genus Spatholobus were put together from earlier research. They were analyzed to assess the probability of biological activity using the PASS server. The network analysis and ligand-protein interaction were looked at using the STITCH web server. The features of the pharmacology are evaluated using the SwissADME web server. According to these results, the substances that best meet the requirements for oral intake include medicarpin, maackiain, lupinalbin A, medioresinol, 8-omethylretusin, biochanin A, isoliquiritigenin, coumestrol, and trigraecum. The activation of caspase-3 and Bcl-2 in the apoptosis and p53 signalling pathways by the nine chemicals suggests that they have the ability to combat breast cancer.
Keywords: Spatholobus, bioactive compounds, network analysis, caspase-3, Bcl-2, p53
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How to cite this article
Sarkar, D., Mondal, A. and Roy, S. (2022). An In silico approach to investigating the anti-breast cancer activity of the plant genus spatholobus. Science Archives, Vol. 3(3), 228-234. https://doi.org/10.47587/SA.2022.3314
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