Antibiotic potential of actinomycetes from different environments against human pathogens and microorganisms of industrial importance: a review

Amita Gaurav Dimri, Abhishek Chauhan and M.L Aggarwal

Department of Microbiology, Shriram Institute for Industrial Research, 19, University Road, Delhi-11007
Amity Institute of Environmental Toxicology, Safety and Management, Amity University, Sector-125,
Noida, Uttar Pradesh, India

akchauhan@amity.edu

Received Date: Dec 23, 2019 / Accepted Date: June 20, 2020 / Published Date: June 26, 2020

Abstract

Actinomycetes are Gram-positive, aerobic and thread like bacteria with high DNA G+C contents. They are free-living, saprophytic, and abundant in soil, water, and colonizing nodulating plants. Actinomycetes assume a significant job in reusing squanders in the earth and they are additionally the makers of thousands of metabolic items, which display organic action. Due to the outstanding history of actinomycetes in the production of bioactive molecules for human interest, a large number of efforts have been made on the isolation, characterization and identification from terrestrial sources in the past half-decade. Secondary metabolites obtained from various potential strains of actinomycetes are very effective against Gram-positive and Gram-negative bacteria. Many researchers both nationally and internationally isolated this potential group of microorganisms from soil, water, sediment etc. and checked their potential antimicrobial activity. In the present review, antibiotic potential of actinomycetes from different environments against human pathogens and microorganisms of industrial importance have been discussed along with novel antimicrobial compounds.

Keywords

Actinomycetes, human pathogens, antimicrobial compounds and antibiotic potential

How to cite this article:

Dimri, A.G., Chauhan, A., Aggarwal, M.L. (2020) Antibiotic potential of actinomycetes from different environments against human pathogens and microorganisms of industrial importance: a review, Science Archives, Vol. 1 (1), 7-24

Crossref DOI

http://dx.doi.org/10.47587/SA.2020.1102

Copyright

This is an open-access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

Abdallaoui, M. S., Kamal, N., & Guessous-Idrissi, N. (2009). Mycoses nosocomiales systémiques à Trichosporon asahii: à propos de trois cas au CHU Ibn Rochd de Casablanca (Maroc). Revue Francophone des Laboratoires,(416), 15-18.

Alharbi, S. A., Arunachalam, C., Murugan, A. M., & Wainwright, M. (2012). Antibacterial activity of actinomycetes isolated from terrestrial soil of Saudi Arabia. Journal of Food, Agriculture & Environment, 10(2), 1093-1097.

Anansiriwattana, W., Tanasupawat, S., Amnuoypol, S., & Suwanborirux, K. (2006). Identification and antimicrobial activities of actinomycetes from soils in Samed Island, and geldanamycin from strain PC4-3. Thai J Pharm Sci, 30, 49-56.

Arasu, M. V., Duraipandiyan, V., & Ignacimuthu, S. (2013). Antibacterial and antifungal activities of polyketide metabolite from marine Streptomyces sp. AP-123 and its cytotoxic effect. Chemosphere, 90(2), 479-487.

Arasu, M. V., Duraipandiyan, V., Agastian, P., & Ignacimuthu, S. (2008). Antimicrobial activity of Streptomyces spp. ERI-26 recovered from Western Ghats of Tamil Nadu. Journal de Mycologie Médicale, 18(3), 147-153.

Arasu, M. V., Duraipandiyan, V., Agastian, P., & Ignacimuthu, S. (2009). In vitro antimicrobial activity of Streptomyces spp. ERI-3 isolated from Western Ghats rock soil (India). Journal de Mycologie Médicale, 19(1), 22-28.

Arifuzzaman, M., Khatun, M. R., & Rahman, H. (2010). Isolation and screening of actinomycetes from Sundarbans soil for antibacterial activity. African journal of biotechnology, 9(29), 4615-4619.

Arumugam, M., Mitra, A., Jaisankar, P., Dasgupta, S., Sen, T., Gachhui, R., … & Mukherjee, J. (2010). Isolation of an unusual metabolite 2-allyloxyphenol from a marine actinobacterium, its biological activities and applications. Applied microbiology and biotechnology, 86(1), 109-117.

Asolkar, R. N., Kirkland, T. N., Jensen, P. R., & Fenical, W. (2010). Arenimycin, an antibiotic effective against rifampin-and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. The Journal of antibiotics, 63(1), 37.

Atta, H. M. (2015). Biochemical studies on antibiotic production from Streptomyces sp.: Taxonomy, fermentation, isolation and biological properties. Journal of Saudi Chemical Society, 19(1), 12-22.

Badji, B., Zitouni, A., Mathieu, F., Lebrihi, A., & Sabaou, N. (2006). Antimicrobial compounds produced by Actinomadura sp. AC104 isolated from an Algerian Saharan soil. Canadian journal of microbiology, 52(4), 373-382.

Balachandran, C., Duraipandiyan, V., Emi, N., & Ignacimuthu, S. (2015). Antimicrobial and cytotoxic properties of Streptomyces sp.(ERINLG-51) isolated from Southern Western Ghats. South Indian Journal of Biological Sciences, 1(1), 7-14.

Basilio, A., Gonzalez, I., Vicente, M. F., Gorrochategui, J., Cabello, A., Gonzalez, A., & Genilloud, O. (2003). Patterns of antimicrobial activities from soil actinomycetes isolated under different conditions of pH and salinity. Journal of applied microbiology, 95(4), 814-823.

Bharti, A., Kumar, V., Gusain, O., & Bisht, G. S. (2010). Antifungal activity of actinomycetes isolated from Garhwal region. Journal of Sci. Engg. & Tech. Mgt. Vol, 2, 2.

Binder, S., Levitt, A. M., Sacks, J. J., & Hughes, J. M. (1999). Emerging infectious diseases: public health issues for the 21st century. Science, 284(5418), 1311-1313.

Bizuye, A., Moges, F., & Andualem, B. (2013). Isolation and screening of antibiotic producing actinomycetes from soils in Gondar town, North West Ethiopia. Asian Pacific journal of tropical disease, 3(5), 375-381.

Bruntner, C., Binder, T., Pathom-aree, W., Goodfellow, M., Bull, A. T., Potterat, O., … & Wagner, K. (2005). Frigocyclinone, a novel angucyclinone antibiotic produced by a Streptomyces griseus strain from Antarctica. The Journal of antibiotics, 58(5), 346.

Carlson, J. C., Li, S., Burr, D. A., & Sherman, D. H. (2009). Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp. Journal of natural products, 72(11), 2076-2079.

Castillo, U. F., Strobel, G. A., Ford, E. J., Hess, W. M., Porter, H., Jensen, J. B., … & Stevens, D. (2002). Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscansa. Microbiology, 148(9), 2675-2685.

Castillo, U. F., Strobel, G. A., Mullenberg, K., Condron, M. M., Teplow, D. B., Folgiano, V., … & Codde, M. (2006). Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from Streptomyces NRRL 3052. FEMS Microbiology letters, 255(2), 296-300.

Castillo, U., Harper, J. K., Strobel, G. A., Sears, J., Alesi, K., Ford, E., … & Yaver, D. (2003). Kakadumycins, novel antibiotics from Streptomyces sp. NRRL 30566, an endophyte of Grevillea pteridifolia. FEMS Microbiology Letters, 224(2), 183-190.

Ceylan, O., Okmen, G., & Ugur, A. (2008). Isolation of soil Streptomyces as source antibiotics active against antibiotic-resistant bacteria. EurAsian Journal of BioSciences, 2(9), 73-82.

Chaudhary, H. S., Yadav, J., Shrivastava, A. R., Singh, S., Singh, A. K., & Gopalan, N. (2013). Antibacterial activity of actinomycetes isolated from different soil samples of Sheopur (A city of central India). Journal of advanced pharmaceutical technology & research, 4(2), 118.

Cuesta, G., García-de-la-Fuente, R., Abad, M., & Fornes, F. (2012). Isolation and identification of actinomycetes from a compost-amended soil with potential as biocontrol agents. Journal of Environmental Management, 95, S280-S284.

Das, A., Bhattacharya, S., Mohammed, A. Y. H., & Rajan, S. S. (2014). In vitro antimicrobial activity and characterization of mangrove isolates of streptomycetes effective against bacteria and fungi of nosocomial origin. Brazilian Archives of Biology and Technology, 57(3), 349-356.

Deepa, L. S., Gowthami, K., & Kumar, K. S. (2011). In vivo screening of antimicrobial activity of soil Actinomycetes against human pathogens. World Journal of Agricultural Sciences, 7(5), 624-628.

Deepthi, M. K., Sudhakar, M. S., & Devamma, M. N. (2012). Isolation and screening of Streptomyces sp. from Coringa mangrove soils for enzyme production and antimicrobial activity. International J of Pharmaceutical, Chemical and Biological Sciences, 2(1), 110-116.

Dehnad, A., Parsa, L., Bakhshi, R., & Mokhtarzadeh, A. (2010). Investigation of antibacterial activity of Streptomycetes isolates from soil samples, West of Iran. African Journal of Microbiology Research, 4(14), 1542-1549.

Donadio, S., Carrano, L., Brandi, L., Serina, S., Soffientini, A., Raimondi, E., … & Gualerzi, C. O. (2002). Targets and assays for discovering novel antibacterial agents. Journal of biotechnology, 99(3), 175-185.

El-Gendy, M. M., Hawas, U. W., & Jaspars, M. (2008). Novel bioactive metabolites from a marine derived bacterium Nocardia sp. ALAA 2000. The Journal of antibiotics, 61(6), 379.

El-khawaga, M. A., & Megahed, M. M. M. (2012). Antibacterial and insecticidal activity of actinomycetes isolated from sandy soil of (Cairo-Egypt). Egypt Acad J Biol Sci, 4(1), 53-67.

Engelhardt, K., Degnes, K. F., Kemmler, M., Bredholt, H., Fjærvik, E., Klinkenberg, G., … & Zotchev, S. B. (2010). Production of a new thiopeptide antibiotic, TP-1161, by a marine Nocardiopsis species. Appl. Environ. Microbiol., 76(15), 4969-4976.

Ezra, D., Castillo, U. F., Strobel, G. A., Hess, W. M., Porter, H., Jensen, J. B., … & Hunter, M. (2004). Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp.(MSU-2110) endophytic on Monstera sp. Microbiology, 150(4), 785-793.

Fguira, L. F. B., Fotso, S., Ameur-Mehdi, R. B., Mellouli, L., & Laatsch, H. (2005). Purification and structure elucidation of antifungal and antibacterial activities of newly isolated Streptomyces sp. strain US80. Research in Microbiology, 156(3), 341-347.

Fiedler, H. P., Bruntner, C., Riedlinger, J., Bull, A. T., Knutsen, G., Goodfellow, M., … & Schneider, K. (2008). Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora. The Journal of antibiotics, 61(3), 158.

Ganesan, P., Reegan, A. D., David, R. H. A., Gandhi, M. R., Paulraj, M. G., Al-Dhabi, N. A., & Ignacimuthu, S. (2017). Antimicrobial activity of some actinomycetes from Western Ghats of Tamil Nadu, India. Alexandria journal of medicine, 53(2), 101-110.

Gaskell, E. E., Sihanonth, P., Rostron, C., Hutcheon, G. A., & Hobbs, G. (2010). Isolation and identification of mucinolytic actinomycetes. Antonie van Leeuwenhoek, 97(3), 211-220.

Gebreyohannes, G., Moges, F., Sahile, S., & Raja, N. (2013). Isolation and characterization of potential antibiotic producing actinomycetes from water and sediments of Lake Tana, Ethiopia. Asian pacific journal of Tropical biomedicine, 3(6), 426-435.

Gopinath,B.V, Vootla, P.K., Jyothi,, R, & Reddy, S.K. (2013). Antimicrobial activity of actinomycetes isolated from coal mine soils of godavari belt region, AP, India. Asian Journal of Experimental Biological Sciences,(4) 518-523.

Gorajana, A., Kurada, B. V., Peela, S., Jangam, P., Vinjamuri, S., Poluri, E., & Zeeck, A. (2005). 1-Hydroxy-1-norresistomycin, a new cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN 1/7. The Journal of antibiotics, 58(8), 526.

Grasso, L.L., Martino, D.C, & Alduina, R. Production of Antibacterial Compounds from Actinomycetes. In Actinobacteria-Basics and Biotechnological Applications. 2016. IntechOpen.

Guan, S. H., Sattler, I., Lin, W. H., Guo, D. A., & Grabley, S. (2005). p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte: Streptomyces griseus subsp. Journal of natural products, 68(8), 1198-1200.

Gurung, T. D., Sherpa, C., Agrawal, V. P., & Lekhak, B. (2009). Isolation and characterization of antibacterial actinomycetes from soil samples of Kalapatthar, Mount Everest Region. Nepal Journal of Science and Technology, 10, 173-182.

Hohmann, C., Schneider, K., Bruntner, C., Irran, E., Nicholson, G., Bull, A. T., … & Beil, W. (2009). Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937. The Journal of antibiotics, 62(2), 99.

Holmalahti, J., Raatikainen, O., Von Wright, A., Laatsch, H., Spohr, A., Lyngberg, O. K., & Nielsen, J. (1998). Production of dihydroabikoviromycin by Streptomyces anulatus: production parameters and chemical characterization of genotoxicity. Journal of applied microbiology, 85(1), 61-68.

Huang, H., Lv, J., Hu, Y., Fang, Z., Zhang, K., & Bao, S. (2008). Micromonospora rifamycinica sp. nov., a novel actinomycete from mangrove sediment. International journal of systematic and evolutionary microbiology, 58(1), 17-20.

Huang, H., Wu, X., Yi, S., Zhou, Z., Zhu, J., Fang, Z., … & Bao, S. (2009). Rifamycin S and its geometric isomer produced by a newly found actinomycete, Micromonospora rifamycinica. Antonie Van Leeuwenhoek, 95(2), 143.

Huang, S. X., Zhao, L. X., Tang, S. K., Jiang, C. L., Duan, Y., & Shen, B. (2009). Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600. Organic letters, 11(6), 1353-1356.

Ilić, S. B., Konstantinović, S. S., & Todorović, Z. B. (2005). UV/VIS analysis and antimicrobial activity of Streptomyces isolates. Facta universitatis series: Med Biol, 12, 44-46.

Iznaga, Y., Lemus, M., González, L., Garmendia, L., Nadal, L., & Vallin, C. (2004). Antifungal activity of actinomycetes from Cuban soils. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 18(6), 494-496.

Jeffrey, L. S. H., Sahilah, A. M., Son, R., & Tosiah, S. (2007). Isolation and screening of actinomycetes from Malaysian soil for their enzymatic and antimicrobial activities. Journal of tropical agriculture and food science, 35(1), 159.

Jiang, Z. K., Tuo, L., Huang, D. L., Osterman, I. A., Tyurin, A. P., Liu, S. W., … & Li, F. N. (2018). Diversity, novelty, and antimicrobial activity of endophytic actinobacteria from mangrove plants in Beilun Estuary National Nature Reserve of Guangxi, China. Frontiers in microbiology, 9, 868.

Jiménez-Esquilín, A. E., & Roane, T. M. (2005). Antifungal activities of actinomycete strains associated with high-altitude sagebrush rhizosphere. Journal of Industrial Microbiology and Biotechnology, 32(8), 378-381.

Jones, K. E., Patel, N. G., Levy, M. A., Storeygard, A., Balk, D., Gittleman, J. L., & Daszak, P. (2008). Global trends in emerging infectious diseases. Nature, 451(7181), 990.

Jose, P. A., & Jebakumar, S. R. D. (2013). Diverse actinomycetes from Indian coastal solar salterns-a resource for antimicrobial screening. J. Pure Appl. Microbiol, 7, 2569-2575.

Kavitha, A., Prabhakar, P., Vijayalakshmi, M., & Venkateswarlu, Y. (2009). Production of bioactive metabolites by Nocardia levis MK‐VL_113. Letters in applied microbiology, 49(4), 484-490.

Keller, S., Nicholson, G., Drahl, C., Sorensen, E., Fiedler, H. P., & Süssmuth, R. D. (2007). Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032. The Journal of antibiotics, 60(6), 391.

Kharat, K. R., Kharat, A., & Hardikar, B. P. (2009). Antimicrobial and cytotoxic activity of Streptomyces sp. from Lonar Lake. African Journal of Biotechnology, 8(23).

Kitouni, M., Boudemagh, A., Oulmi, L., Reghioua, S., Boughachiche, F., Zerizer, H., … & Boiron, P. (2005). Isolation of actinomycetes producing bioactive substances from water, soil and tree bark samples of the north–east of Algeria. Journal de Mycologie Médicale, 15(1), 45-51.

Kock, I., Maskey, R. P., Biabani, M. F., Helmke, E., & Laatsch, H. (2005). 1-Hydroxy-1-norresistomycin and resistoflavin methyl ether: new antibiotics from marine-derived streptomycetes. The Journal of antibiotics, 58(8), 530.

Kumar, N., Singh, R. K., Mishra, S. K., Singh, A. K., & Pachouri, U. C. (2010). Isolation and screening of soil Actinomycetes as source of antibiotics active against bacteria. International Journal of Microbiology Research, 2(2), 12.

Kumar, P. S., Duraipandiyan, V., & Ignacimuthu, S. (2014). Isolation, screening and partial purification of antimicrobial antibiotics from soil Streptomyces sp. SCA 7. The Kaohsiung journal of medical sciences, 30(9), 435-446.

Kumar, V., Bharti, A., Negi, Y. K., Gusain, O., Pandey, P., & Bisht, G. S. (2012). Screening of actinomycetes from earthworm castings for their antimicrobial activity and industrial enzymes. Brazilian Journal of Microbiology, 43(1), 205-214.

Kwon, H. C., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2006). Marinomycins A− D, antitumor-antibiotics of a new structure class from a marine actinomycete of the recently discovered genus “Marinispora”. Journal of the American Chemical Society, 128(5), 1622-1632.

Lavin, P. L., Yong, S. T., Wong, C. M., & De Stefano, M. (2016). Isolation and characterization of Antarctic psychrotroph Streptomyces sp. strain INACH3013. Antarctic Science, 28(6), 433-442.

Lederberg, J., Hamburg, M. A., & Smolinski, M. S. (Eds.). (2003). Microbial threats to health: emergence, detection, and response. National Academies Press.

Leiva, S., Yáñez, M., Zaror, L., Rodríguez, H., & García-Quintana, H. (2004). Actividad antimicrobiana de actinomycetes aislados desde ambientes acuáticos del sur de Chile. Revista médica de Chile, 132(2), 151-159.

Lu C, & Shen, Y. (2003) A new macrolide antibiotic with antitumor activity produced by Streptomyces sp. CS, a commensal microbe of Maytenus hookeri. The Journal of antibiotics,56(4):415-418.

Lu, C., & Shen, Y. (2004). Two new macrolides produced by Streptomyces sp. CS. The Journal of antibiotics, 2004; 57(9), 597-600.

Maataoui, H., Iraqui, M., Jihani, S., Ibnsouda, S, & Haggoud, A. Isolation, characterization and antimicrobial activity of a Streptomyces strain isolated from deteriorated wood. African Journal of Microbiology Research, 8(11): 1178-1186.

Macherla, V. R., Liu, J., Bellows, C., Teisan, S., Nicholson, B., Lam, K. S., & Potts, B. C. (2005). Glaciapyrroles A, B, and C, pyrrolosesquiterpenes from a Streptomyces sp. isolated from an Alaskan marine sediment. Journal of natural products, 68(5), 780-783.

Macherla, V. R., Liu, J., Sunga, M., White, D. J., Grodberg, J., Teisan, S., … & Potts, B. C. (2007). Lipoxazolidinones A, B, and C: antibacterial 4-oxazolidinones from a marine actinomycete isolated from a Guam marine sediment. The Journal of Natural Products, 70(9), 1454-1457.

\Manam, R. R., Teisan, S., White, D. J., Nicholson, B., Grodberg, J., Neuteboom, S. T., … & Potts, B. C. (2005). Lajollamycin, a Nitro-tetraene Spiro-β-lactone-γ-lactam Antibiotic from the Marine Actinomycete Streptomyces n odosus. Journal of natural products, 68(2), 240-243.

Mathur, N., Paliwal, A., Sharma, P., Kumar, M., & Bhatnagar, P. (2012). Antimicrobial Compound from Streptomyces Isolate Characterized Using HPLC. Universal Journal of Environmental Research & Technology, 2(4).

Maya, G., Gisha, G., & Hatha, A. A. M. (2010). Diversity and antibacterial activity of actinomycetes from wetland. The South Pacific Journal of Natural and Applied Sciences, 28(1), 52-57.

McArthur, K. A., Mitchell, S. S., Tsueng, G., Rheingold, A., White, D. J., Grodberg, J., … & Potts, B. C. (2008). Lynamicins A− E, chlorinated bisindole pyrrole antibiotics from a novel marine Actinomycete. Journal of Natural Products, 71(10), 1732-1737.

Mohanraj, G., & Sekar, T. (2013). Isolation and screening of actinomycetes from marine sediments for their potential to produce antimicrobials. Int. J. Life Sci. Bt & Pharm. Res, 2(3): 116-125.

Morens, D.M., Folkers, G.K., Fauci, A.S. (2004) The challenge of emerging and reemerging Infectious diseases. Nature, 430:242–9.

Naikpatil, S.V., & Rathod, J.L. (2011) Selective isolation and antimicrobial activity of rare actinomycetes from mangrove sediment of Karwar. Journal of Ecobiotechnology.

Nanjwade, B., Chandrashekhara, S., Goudanavar, P., Shamarez, A., & Manvi, F. (2010). Production of antibiotics from soil-isolated actinomycetes and evaluation of their antimicrobial activities. Tropical Journal of Pharmaceutical Research, 9(4).

Nedialkova, D., & Naidenova, M. (2005). Screening the antimicrobial activity of actinomycetes strains isolated from Antarctica.

Nishimura, T., Meguro, A., Hasegawa, S., Nakagawa, Y., Shimizu, M., & Kunoh, H. (2002). An endophytic actinomycete, Streptomyces sp. AOK-30, isolated from mountain laurel and its antifungal activity. Journal of general plant pathology, 68(4), 390-397.

Nurkanto, A., Julistiono, H., Agusta, A., & Sjamsuridzal, W. (2012). Screening antimicrobial activity of actinomycetes isolated from Raja Ampat, West Papua, Indonesia. Makara Journal of Science, 21-26.

Oh, D. C., Gontang, E. A., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2008). Salinipyrones and pacificanones, mixed-precursor polyketides from the marine actinomycete Salinispora pacifica. Journal of natural products, 71(4), 570-575.

Okudoh, V. I., & Wallis, F. M. (2007). Antimicrobial activity of rare actinomycetes isolated from natural habitats in KwaZulu-Natal, South Africa. South African journal of science, 103(5-6), 216-222.

Oskay, A. M., Üsame, T., & Cem, A. (2004). Antibacterial activity of some actinomycetes isolated from farming soils of Turkey. African journal of Biotechnology, 3(9), 441-446.

Pandey, A., Ali, I., Butola, K. S., Chatterji, T., & Singh, V. (2011). Isolation and characterization of Actinomycetes from soil and evaluation of antibacterial activities of Actinomycetes against pathogens. International journal of applied biology and pharmaceutical technology, 2(4), 384-392.

Pandey, B., Ghimire, P., & Agrawal, V. P. (2004). Studies on the antibacterial activity of the Actinomycetes isolated from the Khumbu Region of Nepal. J. Biol. Sci, 23, 44-53.

Passari, A. K., Mishra, V. K., Saikia, R., Gupta, V. K., & Singh, B. P. (2015). Isolation, abundance and phylogenetic affiliation of endophytic actinomycetes associated with medicinal plants and screening for their in vitro antimicrobial biosynthetic potential. Frontiers in microbiology, 6, 273.

Patel, J. D., Parmar, M., Patel, P., Rohit, P., Taviyad, R., Ansari, P., … & Singh, P. K. (2014). Dynamism of antimicrobial activity of actinomycetes—a case study from undisturbed microbial niche. Advances in Microbiology, 4(06), 324.

Patil, H. J., Srivastava, A. K., Singh, D. P., Chaudhari, B. L., & Arora, D. K. (2011). Actinomycetes mediated biochemical responses in tomato (Solanum lycopersicum) enhances bioprotection against Rhizoctonia solani. Crop protection, 30(10), 1269-1273.

Poosarla, A., & Krishna, R. M. (2013). Isolation of potent antibiotic producing Actinomycetes from marine sediments of Andaman and Nicobar Marine Islands. Journal of Microbiology and Antimicrobials, 5(1), 6-12.

Pullen, C., Schmitz, P., Meurer, K., Bamberg, D. D. V., Lohmann, S., Franca, S. D. C., … & Gräfe, U. (2002). New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta, 216(1), 162-167.

Rahman, M., Islam, M. Z., Islam, M., & Ul, A. (2011). Antibacterial activities of Actinomycete isolates collected from soils of Rajshahi, Bangladesh. Biotechnology research international, 2011.

Ramesh, S., & Mathivanan, N. (2009). Screening of marine actinomycetes isolated from the Bay of Bengal, India for antimicrobial activity and industrial enzymes. World Journal of Microbiology and Biotechnology, 25(12), 2103-2111.

eddy, N. G., Ramakrishna, D. P. N., & Raja Gopal, S. V. (2011). A morphological, physiological and biochemical studies of marine Streptomyces rochei (MTCC 10109) showing antagonistic activity against selective human pathogenic microorganisms. Asian J Biol Sci, 4(1), 1-14.

Rosa, L. H., Machado, K. M. G., Jacob, C. C., Capelari, M., Rosa, C. A., & Zani, C. L. (2003). Screening of Brazilian basidiomycetes for antimicrobial activity. Memórias do Instituto Oswaldo Cruz, 98(7), 967-974.

Sacramento, D. R., Coelho, R. R. R., Wigg, M. D., Linhares, L. F. D. T. L., dos Santos, M. G. M., Semêdo, L. T. D. A. S., & da Silva, A. J. R. (2004). Antimicrobial and antiviral activities of an actinomycete (Streptomyces sp.) isolated from a Brazilian tropical forest soil. World Journal of Microbiology and Biotechnology, 20(3), 225-229.

Sathiyaseelan, K., & Stella, D. (2011). Isolation, identification and antimicrobial activity of marine actinomycetes isolated from Parangipettai. Recent Research in Science and Technology, 3(9).

\Selvin, J., Shanmughapriya, S., Gandhimathi, R., Kiran, G. S., Ravji, T. R., Natarajaseenivasan, K., & Hema, T. A. (2009). Optimization and production of novel antimicrobial agents from sponge associated marine actinomycetes Nocardiopsis dassonvillei MAD08. Applied microbiology and biotechnology, 83(3), 435.

Sengupta, S., Pramanik, A., Ghosh, A., & Bhattacharyya, M. (2015). Antimicrobial activities of actinomycetes isolated from unexplored regions of Sundarbans mangrove ecosystem. BMC microbiology, 15(1), 170.

Sharma, D., Kaur, T., Chadha, B. S., & Manhas, R. K. (2011). Antimicrobial activity of actinomycetes against multidrug resistant Staphylococcus aureus, E. coli and various other pathogens. Tropical Journal of Pharmaceutical Research, 10(6), 801-808.

Sharma, D., Mayilraj, S., & Manhas, R. K. (2014). Streptomyces amritsarensis sp. nov., exhibiting broad-spectrum antimicrobial activity. Antonie Van Leeuwenhoek, 105(5), 943-949.

Sharma, P., Kalita, M. C., & Thakur, D. (2016). Broad spectrum antimicrobial activity of forest-derived soil actinomycete, Nocardia sp. PB-52. Frontiers in microbiology, 7, 347.

Silva, W. A., Pinheiro, A. M., Jahns, B., Bögli-Stuber, K., Droz, S., & Zimmerli, S. (2011). Breast abscess due to Actinomyces europaeus. Infection, 39(3), 255-258.

Singh, L. S., Baruah, I., & Bora, T. C. (2006). Actinomycetes of Loktak habitat: isolation and screening for antimicrobial activities. Biotechnology, 5(2), 217-221.

Singh, L. S., Sharma, H., & Talukdar, N. C. (2014). Production of potent antimicrobial agent by actinomycete, Streptomyces sannanensis strain SU118 isolated from phoomdi in Loktak Lake of Manipur, India. BMC microbiology, 14(1), 278.

Singh, S., Kumar, P., Gopalan, N., Shrivastava, B., Kuhad, R. C., & Chaudhary, H. S. (2012). Isolation and partial characterization of actinomycetes with antimicrobial activity against multidrug resistant bacteria. Asian Pacific Journal of Tropical Biomedicine, 2(2), S1147-S1150.

Singh, V., Haque, S., Singh, H., Verma, J., Vibha, K., Singh, R., … & Tripathi, C. K. M. (2016). Isolation, screening, and identification of novel isolates of actinomycetes from India for antimicrobial applications. Frontiers in microbiology, 7, 1921.

Socha, A. M., LaPlante, K. L., & Rowley, D. C. (2006). New bisanthraquinone antibiotics and semi-synthetic derivatives with potent activity against clinical Staphylococcus aureus and Enterococcus faecium isolates. Bioorganic & medicinal chemistry, 14(24), 8446-8454.

Solanki, R., Khanna, M., & Lal, R. (2008). Bioactive compounds from marine actinomycetes. Indian journal of microbiology, 48(4), 410-431.

Sujatha, P., Raju, K. B., & Ramana, T. (2005). Studies on a new marine streptomycete BT-408 producing polyketide antibiotic SBR-22 effective against methicillin resistant Staphylococcus aureus. Microbiological research, 160(2), 119-126.

Suthindhiran, K., & Kannabiran, K. (2010). Diversity and exploration of bioactive marine actinomycetes in the Bay of Bengal of the Puducherry coast of India. Indian journal of microbiology, 50(1), 76-82.

Sweetline, C., Usha, R., & Palaniswamy, M. (2012). Antibacterial activity of actinomycetes from Pichavaram Mangrove of Tamil Nadu. Applied Journal of Hygiene, 1(2), 15-18.

Thenmozhi, M, & Kannabiran, K. (2012). Antimicrobial and antioxidant properties of marine actinomycetes Streptomyces sp VITSTK7. Oxidants and Antioxidants in Medical Science, 1(1):51-57.

Thumar, J. T., Dhulia, K., & Singh, S. P. (2010). Isolation and partial purification of an antimicrobial agent from halotolerant alkaliphilic Streptomyces aburaviensis strain Kut-8. World Journal of Microbiology and Biotechnology, 26(11), 2081-2087.

Usha, R., Ananthaselvi, P., Venil, C. K., & Palaniswamy, M. (2010). Antimicrobial and antiangiogenesis activity of Streptomyces parvulus KUAP106 from mangrove soil. Eur J Biol Sci, 2(4), 77-83.

Valli, S., Suvathi, S. S., Aysha, O. S., Nirmala, P., Vinoth, K. P., & Reena, A. (2012). Antimicrobial potential of Actinomycetes species isolated from marine environment. Asian Pacific Journal of Tropical Biomedicine, 2(6), 469-473.

Varghese, R., Nishamol, S., Suchithra, R., Jyothy, S., & Hatha, A. M. (2012). Distribution and antibacterial activity of actinomycetes from Shola soils of tropical Montane forest in Kerala, South India. J. Environ, 1(3), 93-99.

Vijayakumar, R., Murugesan, S., & Panneerselvam, A. (2010). Isolation, characterization and antimicrobial activity of actinobacteria from point calimere coastal region, east coast of India. Int Res J Pharam, 1, 358-365.

Vijayakumar, R., Panneerselvam, K., Muthukumar, C., Thajuddin, N., Panneerselvam, A., & Saravanamuthu, R. (2012). Optimization of antimicrobial production by a marine actinomycete Streptomyces afghaniensis VPTS3-1 isolated from Palk Strait, East Coast of India. Indian journal of microbiology, 52(2), 230-239.

Vimal, V., Rajan, B. M., & Kannabiran, K. (2009). Antimicrobial activity of marine actinomycete, Nocardiopsis sp. VITSVK 5 (FJ973467). Asian J Med Sci, 1(2), 57-63.

Yücel, S. E. M. R. A., & Yamaç, M. U. S. T. A. F. A. (2010). Selection of Streptomyces isolates from Turkish karstic caves against antibiotic resistant microorganisms. Pak. J. Pharm. Sci, 23(1), 1-6.

Zhao, P. J., Fan, L. M., Li, G. H., Zhu, N., & Shen, Y. M. (2005). Antibacterial and antitumor macrolides fromstreptomyces sp. Is9131. Archives of pharmacal research, 28(11), 1228-1232.

Zhou, M. Y. (1998). Identification of marine actinomycetes S-216 strain and its biosynthetic conditions of antifungal antibiotic. J. Xiamen Univ. Nat. Sci., 37, 109-114.

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