Majid Mohammed Mahmood1, Zenab Ghanim Younus Al-Ameen2, Aras Fathi Al-Barazanchi3, and Taghreed Alkhanchi5

 1-Unit of Zoonotic Diseases, College of Veterinary Medicine, University of Baghdad, Iraq

 2-College of Pharmacy, University of Baghdad, Baghdad, Iraq.

 3-Pediatric Hospital, Halabja/ Kurdistan Region of Iraq and University of Sulimanyha, College of Medicine

  4College of Pharmacy, University of Baghdad. Baghdad, Iraq

*Corresponding author: dr.Majid.Mahmood80@covm.uobaghdad.edu.iq

Received: May 17, 2021 / Revised: June 17, 2021/ Accepted: June 21, 2021

Abstract

Therapeutic protocol for COVID-19 has been written in this manuscript and explained in-depth with detailed information. The protocols are divided into 3 main sections: generic protocol, the specific protocol for children, and a specific protocol for pregnant women and breast feeders. The basic concept is to treat viral infection symptoms, therefore medicines were selected accordingly. Garlic and onion consumption have been strongly recommended as immuno-stimulants. The advantages of this protocol include: no deaths, cure and recovery within a few days up to one week is guaranteed (cure may extend up to 10 days in very rare cases), no hospital admission, no need for Extracorporeal Membrane Oxygenation (ECMO) machines or any other type of ventilators (CPAP or BPAP). Also, this protocol can be applied without fear of interference with hypertensive or diabetic patients (although betamethasone causes slight temporary hyperglycaemia, this can be easily controlled by taking normal anti-diabetic medicines where there is no drug interaction between the medicines used in this protocol and anti-diabetic medicines) and finally no drug interference between the medicines used in this protocol and the medicines commonly used for asthma, thalassemia and goiter, allergic individuals, autoimmune diseases, heart problems etc. Disadvantages of this protocol include very rare cases of patients who have the previous hypersensitivity to some of the medicines mentioned in this protocol (estimated about less than 10 persons per million cases which is statistically nothing). This protocol has been/is being applied on thousands of COVID-19 patients (all age groups both genders, without causing any complications or deaths). This protocol is currently a national plan across the whole country (Iraq) where Iraqi physicians are using it to treat COVID-19 patients (ongoing work, unpublished data), plus it was circulated all over the Arab homeland. Amazing, promising, and astonishing data has been/is being collected and collated in files and it will be published most probably after getting acceptance of this paper in your respectful decent journal.

Keywords Therapeutic protocol, COVID-19, Children, Pregnant and breast feeders’ women, No complications, No deaths.

How to cite this article:

Mahmood, M. M., Al-Ameen, Z. G. Y., Al-Barazanchi, A. F., and Alkhanchi, T. (2021). Applied Successful Therapeutic Protocol for COVID-19 in Arab Homeland. Science Archives, Vol. 2 (2), 124-134. http://dx.doi.org/10.47587/SA.2021.2212

Copyright

This is an open-access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

ABC. (2020). American Baby and Child (ABC) Law Centers, Reiter and Walsh P.C. Betamethasone: In-Utero Steroids Help Prevent Birth Injuries in Premature Babies. Available at: https://www.abclawcenters.com/practice-areas/neonatal-birth-injuries/neonatal-intensive-care-unit-nicu/premature-birth-treatment/betamethasone-steroids/#:~:text=Antenatal%20betamethasone%20is%20primarily%20used,sticking%20when%20the%20infant%20breathes. Accessed 26 April 2021.

Abu-darwish, M. S.and Al-Ramamneh, E. (2009). The present-day survey of registered and standardized herbal medicines in Jordanian pharmaceutical market. American-Eurasian Journal of Sustainable Agriculture, C(), CC-CC.

Al-Kuraishy, H. M., Al-Naimi, M. S., Lungnier, C. M.and Al-Gareeb, A. I. (2020). Macrolides and COVID-19: An optimum premise. Biomedical Biotechnology Research Journal, 4(3), 189-192.

Andrews, P. L., Cai, W., Rudd, J. A.and Sanger, G. J. (2021). COVID‐19, nauseaandvomiting. Journal of Gastroenterology Hepatology, 36(3), 646-656.

Ang, L., Lee, H. W., Choi, J. Y., Zhang, J. and Lee, M. S. (2020a). Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines. Integrative Medicine Research, 9(2), 100407.

Ang, L., Lee, H. W., Kim, A. and Lee, M. S. (2020b). Herbal medicine for the management of COVID-19 during the medical observation period: A review of guidelines. Integrative Medicine Research, 9(3), 100465.

Anwar, F., Altayb, H. N., Al-Abbasi, F. A., Al-Malki, A. L., Kamal, M. A. and Kumar, V. (2020). Antiviral effects of probiotic metabolites on COVID-19. Journal of Biomolecular Structure Dynamics, 1-10.

Arnardottir, H., Pawelzik, S.-C., Öhlund Wistbacka, U., Artiach, G., Hofmann, R., Reinholdsson, I. and Bäck, M. (2021). Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial. Frontiers in Physiology, 11, 1748.

Asher, A., Tintle, N. L., Myers, M., Lockshon, L., Bacareza, H. and Harris, W. S. (2021). Blood omega-3 fatty acids and death from COVID-19: A pilot study. Prostaglandins, Leukotrienes Essential Fatty Acids, 166, 102250.

Ashfaq, F., Ali, Q., Haider, M., Hafeez, M. and Malik, A. (2021). Therapeutic activities of garlic constituent phytochemicals. Biological Clinical Sciences Research Journal, 2021(1), e007.

Balmeh, N., Mahmoudi, S. and Fard, N. A. (2021). Manipulated bio antimicrobial peptides from probiotic bacteria as proposed drugs for COVID-19 disease. Informatics in Medicine Unlocked, 23, 100515.

Baracchi, D., Francese, S.andTurillazzi, S. (2011). Beyond the antipredatory defence: honey bee venom function as a component of social immunity. Toxicon, 58(6-7), 550-557.

Bhutada, R. S., Rathi, R.andDasar, D. (2020). Immunity boosting diet during Covid 19. International Journal of Research in Pharmaceutical Sciences, 11 (SPL 1), 832-838.

Bisen, P. S. and Emerald, M. (2016). Nutritional and therapeutic potential of garlic and onion (Allium sp.). Current Nutrition Food Science and Nutrition, 12(3), 190-199.

BNF. (2020). British National Formulary (BNF) Textbook Online. Available at: https://www.bnf.org/products/bnf-online/. BMJ Group, RCPCH Publications Ltd and the Royal Pharmaceutical Society of Great Britain 2020. Accessed 26 April 2021.

BNFC. (2020). British National Formulary for Children (BNFC). Published by National Institute for Health and Care Excellence (NICE) online. Available at: https://www.nice.org.uk/bnfc-uk-only. Accessed 26 April 2021. .

Buzby, S. (2020). Rivaroxaban superior to enoxaparin for VTE prevention after nonmajor orthopedic surgery. Cardiology Today, Vascular Medicine. Available at: https://www.healio.com/news/cardiology/20200402/rivaroxaban-superior-to-enoxaparin-for-vte-prevention-after-nonmajor-orthopedic-surgery?fbclid=IwAR3DvAtIUldU5MrT3LXRifERdF0csdP0q2y5QYiN8fRdI812usHM9RpR01U. Accessed 26 April 2021.

Bwire, G. M. (2020). Coronavirus: Why Men are More Vulnerable to Covid-19 Than Women? Sn Comprehensive Clinical Medicine, 2, 874–876.

Cahill, L. S., Whitehead, C. L., Hobson, S. R., Stortz, G., Kingdom, J. C., Baschat, A. andSled, J. G. (2019). Effect of maternal betamethasone administration on feto-placental vascular resistance in the mouse. Biology of Reproduction, 101(4), 823-831.

Capuano, A., Scavone, C., Racagni, G. and Scaglione, F. (2020). NSAIDs in patients with viral infections, including Covid-19: Victims or perpetrators? Pharmacological Research, 157, 104849.

Carroll, W., Strenger, V., Eber, E., Porcaro, F., Cutrera, R., Fitzgerald, D.andLynn, I. B. (2020). European and United Kingdom COVID-19 pandemic experience: The same but different. Paediatric Respiratory Reviews, 35, 50-56.

Cattaneo, M., Bertinato, E. M., Birocchi, S., Brizio, C., Malavolta, D., Manzoni, M. and Orlandi, M. (2020). Pulmonary embolism or pulmonary thrombosis in COVID-19? Is the recommendation to use high-dose heparin for thromboprophylaxis justified? Thrombosis and Haemostasis. Letter to the Editor.

Cattaneo, M. and Morici, N. (2020). Is thromboprophylaxis with high-dose enoxaparin really necessary for COVID-19 patients? A new “prudent” randomised clinical trial. Blood Transfusion, 18(3), 237.

Chakraborty, D. and Majumder, A. (2020). Garlic (Lahsun)–an immunity booster against SARS-CoV-2. Biotica Research Today, 2(8), 755-757.

Conti, P. and Younes, A. (2020). Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection. Journal of Biological Regulators and Homeostatic Agents, 34(2), 71.

Corzo-Martínez, M., Corzo, N. and Villamiel, M. (2007). Biological properties of onions and garlic. Trends in Food Science Technology, 18(12), 609-625.

Cox, M. J., Loman, N., Bogaert, D. and O’grady, J. (2020). Co-infections: potentially lethal and unexplored in COVID-19. The Lancet Microbe, 1(1), e11.

Črnivec, I. G. O., Skrt, M., Šeremet, D., Sterniša, M., Farčnik, D., Štrumbelj, E. and Možina, S. S. (2021). Waste streams in onion production: Bioactive compounds, quercetin and use of antimicrobial and antioxidative properties. Waste Management, 126, 476-486.

Cutolo, M., Smith, V. and Paolino, S. (2020). Understanding immune effects of oestrogens to explain the reduced morbidity and mortality in female versus male COVID-19 patients. Comparisons with autoimmunity and vaccination. Clinical and Experimental Rheumatology, 38, 383-386.

D’Amico, F., Baumgart, D. C., Danese, S. and Peyrin-Biroulet, L. (2020). Diarrhea during COVID-19 infection: pathogenesis, epidemiology, prevention and management. Clinical Gastroenterology Hepatology, 18(8), 1663-1672.

Dandara, C., Dzobo, K. and Chirikure, S. (2020). COVID-19 pandemic and Africa: from the situation in zimbabwe to a case for precision herbal medicine. Omics: a Journal of Integrative Biology, 25(4).

DeBiasi, R. L., Song, X., Delaney, M., Bell, M., Smith, K., Pershad, J. and Harik, N. (2020). Severe COVID-19 in children and young adults in the Washington, DC metropolitan region. Open Forum Infectious Diseases, 7(1), S338.

DeGrandi-Hoffman, G.andChen, Y. (2015). Nutrition, immunity and viral infections in honey bees. Current Opinion in Insect Science, 10, 170-176.

Drugs.com. (2020). Famotidine Pregnancy and Breastfeeding Warnings. Available at: https://www.drugs.com/pregnancy/famotidine.html. Accessed 17 April 2021.

EMC-UK. (2020). Betamethasone 4mg/ml Solution for Injection. RPH Pharmaceuticals AB. Available at: https://www.medicines.org.uk/emc/product/9097/smpc. Accessed 20 April 2021.

EVERYDAY-HEALTH. (2020). EVERYDAY-HEALTH is a team of board-certified medical reviewers. Drugs and Supplements. Betamethasone (Injection). Available at: https://www.everydayhealth.com/drugs/betamethasone. Accessed 20 April 2021.

Fukano, K., Tsukuda, S., Watashi, K.and Wakita, T. (2019). Concept of viral inhibitors via NTCP. In: Seminars in liver disease: 2019: Thieme Medical Publishers, 078-085.

Fan, A. Y., Gu, S. and Alemi, S. F. (2020). Chinese herbal medicine for COVID-19: Current evidence with systematic review and meta-analysis. Journal of Integrative Medicine, 18(5), 385-394.

Faqah, A., Sheikh, H., Bakar, M. A., Tayyaab, F.andKhawaja, S. (2020). Comparative analysis of enoxaparin versus rivaroxaban in the treatment of cancer associated venous thromboembolism: experience from a tertiary care cancer centre. Thrombosis Journal, 18(1), 8. doi:10.1186/s12959-020-00221-2

Favaloro, E. J. and Thachil, J. (2020). Reporting of D-dimer data in COVID-19: some confusion and potential for misinformation. Clinical Chemistry Laboratory Medicine, 58(8), 1191-1199.

Fathi, N. and Rezaei, N. (2020). Lymphopenia in COVID‐19: Therapeutic opportunities. Cell Biology International, 44(9), 1792-1797.

FitzGerald, G. A. (2020). Misguided drug advice for COVID-19. Science, 367(6485), 1434.

Foissac, F., Zheng, Y., Hirt, D., Lui, G., Bouazza, N., Ville, Y. and Mandelbrot, L. (2020). Maternal betamethasone for prevention of Respiratory Distress Syndrome in neonates: population pharmacokinetic and pharmacodynamic approach. Clinical Pharmacology and Therapeutics, 108(5), 1026-1035.

Freedberg, D. E., Conigliaro, J., Wang, T. C., Tracey, K. J., Callahan, M. V., Abrams, J. A. and O’Donnell, M. R. (2020). Famotidine use is associated with improved clinical outcomes in hospitalized COVID-19 patients: a propensity score matched retrospective cohort study. Gastroenterology, 159(3), 1129-1131.

Fu, Y., Wang, Y., Gao, H., Li, D., Jiang, R., Ge, L. and Xu, K. (2021). Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut MicrobiotaandIntestinal Immunity. Mediators of Inflammation, 2021, 1-11.

Garcia-Olivé, I., Sintes, H., Radua, J., Capa, J. A. and Rosell, A. (2020). D-dimer in patients infected with COVID-19 and suspected pulmonary embolism. Respiratory Medicine, 169, 106023.

Garcia-Vidal, C., Sanchez-Rodriguez, I., Simonetti, A., Burgos, J., Viasus, D., Martin, M. and Carratalà, J. (2017). Levofloxacin versus azithromycin for treating legionella pneumonia: a propensity score analysis. Clinical Microbiology and Infection, 23(9), 653-658.

Gorbalenya, A. E., Baker, S. C., Baric, R., Groot, R. J. d., Drosten, C., Gulyaeva, A. A. and Neuman, B. W. (2020). Severe acute respiratory syndrome-related coronavirus: The species and its viruses–a statement of the Coronavirus Study Group. BioRxiv. doi:http://dx.doi.org/10.1101/2020.02.07.937862v1.

Grandordy, B., Belmatoug, N., Morelle, A., De Lauture, D. and Marsac, J. (1987). Effect of betamethasone on airway obstruction and bronchial response to salbutamol in prednisolone resistant asthma. Thorax, 42(1), 65-71.

Hamada, A. M. (2020). Vitamins, omega-3, magnesium, manganese and thyme can boost our immunity and protect against COVID-19. European Journal of  Biological Research, 10(4), 271-295.

Han, M. S., Seong, M.-W., Kim, N., Shin, S., Cho, S., Park, H. and Choi, E. H. (2020). Viral RNA Load in Mildly Symptomatic and Asymptomatic Children with COVID-19, Seoul. Emerging Infectious Diseases, 26(10).

Hathaway III, D., Pandav, K., Patel, M., Riva-Moscoso, A., Singh, B. M., Patel, A. and Sanchez-Dopazo, R. (2020). Omega 3 Fatty Acids and COVID-19: A Comprehensive Review. Infection Chemotherapy, 52(4), 478.

He, T., Qu, R., Qin, C., Zheyi, W., Zhang, Y., Shao, X.andLu, T. (2020). Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury. Saudi Pharmaceutical Journal, 28(9), 1138-1148.

Huang, H.-Y., Caballero, B., Chang, S., Alberg, A. J., Semba, R. D., Schneyer, C. R. andProkopowicz, G. (2006). The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference. Annals of Internal Medicine, 145(5), 372-385.

Janowitz, T., Gablenz, E., Pattinson, D., Wang, T. C., Conigliaro, J., Tracey, K. and Tuveson, D. (2020). Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: a case series. Gut, 69(9), 1592-1597.

Jianguo, Y., Changping, D. and Min, Z. (2002). Levofloxacin for short-course treatment in 50 patients with typhoid fever. China Journal of Modern Medicine, 3, 26.

Jóźwiak-Bebenista, M. And Nowak, J. Z. (2014). Paracetamol: mechanism of action, applications and safety concern. Acta Poloniae Pharmaceutica, 71(1), 11-23.

Kaduk, J. (2019). Commercial multivitamin: Centrum A to Zn. International Tables for Crystallography, 3.7, 312-313.

Karampela, I. And Dalamaga, M. (2020). Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19? Archives of Medical Research, 51(7), 741-742.

Kashanian, M., Eshraghi, N., Sheikhansari, N., Bordbar, A. And Khatami, E. (2018). Comparison between two doses of betamethasone administration with 12 hours vs. 24 hours intervals on prevention of respiratory distress syndrome: a randomised trial. Journal of Obstetrics and Gynaecology, 38(6), 770-776.

Kjer, J. and Hess, J. (1983). Serum estriol level during treatment with betamethasone in the last trimester of human pregnancy. Acta obstetricia et gynecologica Scandinavica, 62(4), 307-309.

Kwon, S., Lee, W., Jin, C., Jang, I., Jung, W.-S., Moon, S.-K. and Cho, K.-H. (2020). Could herbal medicine (Soshihotang) be a new treatment option for COVID-19?: A Narrative Review. Integrative Medicine Research, 9(3), 100480.

Li, C., Hu, B., Zhang, Z., Qin, W., Zhu, Z., Zhai, Z. and Wang, C. (2020a). D‐dimer triage for COVID‐19. Academic Emergency Medicine, 27(7), 612-613.

Li, X.-Y., Dai, W.-J., Wu, S.-N., Yang, X.-Z. and Wang, H.-G. (2020b). The occurrence of diarrhea in COVID-19 patients. Clinics Research in Hepatology Gastroenterology, 44(3), 284–285.

Li, Y., Li, J., Zhong, D., Zhang, Y., Zhang, Y., Guo, Y. and Jin, R. (2020c). Clinical practice guidelines and experts’ consensuses of traditional Chinese herbal medicine for novel coronavirus (COVID-19): protocol of a systematic review. Systematic Reviews, 9(1), 1-5.

Li, Y., Liu, X., Guo, L., Li, J., Zhong, D., Zhang, Y. and Jin, R. (2020d). Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis. Systematic Reviews, 9, 1-6.

Lisanti, M. (2020). Could these senolytic drugs halt the spread of COVID-19? Health Europa. Published by Pan European Networks Ltd in Congleton, United Kingdom. – Co. Reg. No: 7652562. Available at: https://www.healtheuropa.eu/could-these-senolytic-drugs-halt-the-spread-of-covid-19/100604/. Accessed 21 April 2021.

Llitjos, J. F., Leclerc, M., Chochois, C., Monsallier, J. M., Ramakers, M., Auvray, M. and Merouani, K. (2020). High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients. Journal of Thrombosis and Haemostasis, 18(7), 1743-1746.

Lodigiani, C., Iapichino, G., Carenzo, L., Cecconi, M., Ferrazzi, P., Sebastian, T. and Alexia, B. (2020). Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thrombosis Research, 191, 9-14.

Luo, X., Ni, X., Lin, J., Zhang, Y., Wu, L., Huang, D. and Cai, Y. (2020). The add-on effect of Chinese herbal medicine on COVID-19: a systematic review and meta-analysis. Phytomedicine, 85, 153282.

Mahammedi, A., Saba, L., Vagal, A., Leali, M., Rossi, A., Gaskill, M. and Bachir, S. (2020). Imaging in Neurological Disease of Hospitalized COVID-19 Patients: An Italian Multicenter Retrospective Observational Study. Radiology, 201933.

Malone, R. W., Tisdall, P., Fremont-Smith, P., Liu, Y., Huang, X.-P., White, K. M. andDelaforge, E. (2020). COVID-19: Famotidine, histamine, mast cells and mechanisms. Frontiers in Pharmacology, 12, 633680.

Mastrobattista, J. M., Patel, N. and Monga, M. (2001). Betamethasone alteration of the one-hour glucose challenge test in pregnancy. The Journal of Reproductive Medicine, 46(2), 83.

Mather, J. F., Seip, R. L. and McKay, R. G. (2020). Impact of famotidine use on clinical outcomes of hospitalized patients with COVID-19. The American Journal of Gastroenterology, 10.14309.

McAllen, M., Kochanowski, S. and Shaw, K. (1974). Steroid aerosols in asthma: an assessment of betamethasone valerate and a 12-month study of patients on maintenance treatment. British Medical Journal, 1(5900), 171-175.

Medscape. (2020). Ondansetron (Rx). Available at: https://reference.medscape.com/drug/zofran-zuplenz-ondansetron-342052. Accessed 05 April 2021.

Middeldorp, S., Coppens, M., van Haaps, T. F., Foppen, M., Vlaar, A. P., Müller, M. C. and Heijmans, J. (2020). Incidence of venous thromboembolism in hospitalized patients with COVID-19. Journal of Thrombosis and Haemostasis, 18(8), 1995-2002.

Miri, S. M., Noorbakhsh, F., Mohebbi, S. R. and Ghaemi, A. (2020). Higher prevalence of asymptomatic or mild COVID‐19 in children, claims and clues. Journal of Medical Virology, 92(11), 2257-2259.

Moyer, V. A. (2014). Vitamin, mineral and multivitamin supplements for the primary prevention of cardiovascular disease and cancer: US Preventive Services Task Force recommendation statement. Annals of  Internal Medicine, 160(8), 558-564.

Nelwan, R., Chen, K. and Paramita, D. (2006). Open study on efficacy and safety of levofloxacin in treatment of uncomplicated typhoid fever. Southeast Asian Journal of Tropical Medicine and Public Health, 37(1), 126.

Neuhouser, M. L., Wassertheil-Smoller, S., Thomson, C., Aragaki, A., Anderson, G. L., Manson, J. E. and Shikany, J. M. (2009). Multivitamin use and risk of cancer and cardiovascular disease in the Women’s Health Initiative cohorts. Archives of Internal Medicine, 169(3), 294-304.

Noreddin, A. M. and Elkhatib, W. F. (2010). Levofloxacin in the treatment of community-acquired pneumonia. Expert Review of Anti-Infective Therapy, 8(5), 505-514.

Noreddin, A. M., Elkhatib, W. F., Cunnion, K. M. and Zhanel, G. G. (2011). Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy. Drug, Healthcare and Patient Safety, 3, 59.

Ohe, M., Shida, H., Jodo, S., Kusunoki, Y., Seki, M., Furuya, K. and Goudarzi, H. (2020). Macrolide treatment for COVID-19: Will this be the way forward? Bioscience Trends, 14(2), 159-160.

Ozbalak, M., Besisik, S. K., Tor, Y. B., Medetalibeyoglu, A., Kose, M. and Senkal, N. (2021). Initial complete blood count score and predicting disease progression in COVID-19 patients. American Journal of Blood Research, 11(1), 77.

Pachetti, M., Marini, B., Benedetti, F., Giudici, F., Mauro, E., Storici, P. and Gallo, R. C. (2020). Emerging SARS-CoV-2 mutation hot spots include a novel RNA-dependent-RNA polymerase variant. Journal of Translational Medicine, 18, 1-9.

Panyod, S., Ho, C.-T. and Sheen, L.-Y. (2020). Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective. Journal of Traditional and Complementary Medicine, 10(4), 420-427.

Paprocki, M. (2020). Nonsteroidal anti-inflammatory drugs (NSAIDs) in COVID-19 patient. Disaster and Emergency Medicine Journal, 5(2), 1-2.

Pathan, R. K., Biswas, M. and Khandaker, M. U. (2020). Time series prediction of COVID-19 by mutation rate analysis using recurrent neural network-based LSTM model. Chaos, Solitons Fractals, 138, 110018.

Pawar, Y. and Patil, A. (2020). Garlic: An Immunity Booster Spice during Pandemic Situation. Biotica Research Today, 2(9), 978-980.

Rogero, M. M., Leão, M. d. C., Santana, T. M., de MB Pimentel, M. V., Carlini, G. C., da Silveira, T. F. and Castro, I. A. (2020). Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19. Free Radical Biology Medicine, 156, 190-199.

Schmitz, T., Alberti, C., Ursino, M., Baud, O. and Aupiais, C. (2019). Full versus half dose of antenatal betamethasone to prevent severe neonatal respiratory distress syndrome associated with preterm birth: study protocol for a randomised, multicenter, double blind, placebo-controlled, non-inferiority trial (BETADOSE). BMC Pregnancy and Childbirth, 19(1), 67.

Sharma, G., Volgman, A. S. and Michos, E. D. (2020). Sex Differences in Mortality from COVID-19 Pandemic: Are Men Vulnerable and Women Protected? JACC: Case Reports, 2(9), 1407–1410.

Simone, M., Evans, J. D. and Spivak, M. (2009). Resin collection and social immunity in honey bees. Evolution: International Journal of Organic Evolution, 63(11), 3016-3022.

Singh, R. and Emmady, P. D. (2020). Rivaroxaban. In StatPearls [Internet] (Vol. https://www.ncbi.nlm.nih.gov/books/NBK557502/): StatPearls Publishing.

Singh, V. P., El-Kurdi, B. and Rood, C. (2020). What underlies the benefit of famotidine formulations used during COVID-19? Gastroenterology, 159(3), 1129-1131.

Stewart, M. (2019). Betamethasone soluble tablets. Patient Website is a UK registered trade mark. Available at: https://patient.info/medicine/betamethasone-soluble-tablets. Accessed 20 April 2021.

Tanne, J. H. (2020). Covid-19: FDA approves use of convalescent plasma to treat critically ill patients. BMJ, 368, m1256.

Tan, L., Wang, Q., Zhang, D., Ding, J., Huang, Q., Tang, Y.-Q. and Miao, H. (2020). Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Signal Transduction Targeted Therapy, 5(1), 1-3.

Tavakolpour, S., Rakhshandehroo, T., Wei, E. X. and Rashidian, M. (2020). Lymphopenia during the COVID-19 infection: What it shows and what can be learned. Immunology Letters, 225, 31.

Teagarden, C. M. and Picardo, C. W. (2011). Betamethasone-induced hypokalemic periodic paralysis in pregnancy. Obstetrics and Gynecology, 117(2), 433-435.

Tezer, H. and Demirdağ, T. B. (2020). Novel coronavirus disease (COVID-19) in children. Turkish Journal of Medical Sciences, 50(SI-1), 592-603.

Treibel, T. A., Manisty, C., Burton, M., McKnight, Á., Lambourne, J., Augusto, J. B. and Moon, J. C. (2020). COVID-19: PCR screening of asymptomatic health-care workers at London hospital. The Lancet, 395(10237), 1608-1610.

Trivedi, M. K., Patil, S., Shettigar, H., Bairwa, K. and Jana, S. (2015). Effect of biofield treatment on spectral properties of paracetamol and piroxicam. Chemical Sciences Journal, 6(3), 100098.

Usman, M., Ashraf, M., Khokhar, M. I., Ashiq, B., Masood, M. I., Afzal, S. and Qadir, M. I. (2013). Comparative pharmacokinetics of levofloxacin in healthy volunteers and in patients suffering from typhoid fever. Iranian Journal of Pharmaceutical Research, 12(1), 147.

Vellos, K., Highland, J., Yousefzai, R., Stoddard, A., Johnson, E. and Gaynes, B. I. (2019). Dosage considerations in the combined use of ocular-specific vitamins and nutrients and multivitamin products: A systematic review and analysis. Journal of the American Pharmacists Association, 59(3), 423-431.

Vermund, S. H. and Pitzer, V. E. (2020). Asymptomatic transmission and the infection fatality risk for COVID-19: Implications for school reopening. Clinical Infectious Diseases, 72(9), 1493–1496.

Vilar, S. and Isom, D. G. (2021). One year of SARS-CoV-2: How much has the virus changed? Biology, 10(2), 91.

Waltl, E. E., Selb, R., Eckl-Dorna, J., Mueller, C. A., Cabauatan, C. R., Eiwegger, T. and Valenta, R. (2018). Betamethasone prevents human rhinovirus-and cigarette smoke-induced loss of respiratory epithelial barrier function. Scientific Rseports, 8(1), 1-10.

Wang, Y., Hou, H., Wang, W. and Wang, W. (2020a). Combination of CT and RT-PCR in the screening or diagnosis of COVID-19. Journal of Global Health, 10(1), 010347.

Wang, Y., Zhu, F., Wang, C., Wu, J., Liu, J., Chen, X. and Lu, X. (2020b). Children Hospitalized With Severe COVID-19 in Wuhan. The Pediatric Infectious Disease Journal, 39(7), e91-e94.

WHO. (2020). WHO announces COVID-19 outbreak a pandemic. Available at: https://www.euro.who.int/en/health-topics/health-emergencies/coronavirus-covid-19/news/news/2020/3/who-announces-covid-19-outbreak-a-pandemic. Accessed 12 June 2020.

Wichmann, D., Sperhake, J.-P., Lütgehetmann, M., Steurer, S., Edler, C., Heinemann, A. and Schröder, A. S. (2020). Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med, 173(4), 268-277.

Williams, C. M., Maher, C. G., Latimer, J., McLachlan, A. J., Hancock, M. J., Day, R. O. and Lin, C.-W. C. (2014). Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial. The Lancet, 384(9954), 1586-1596.

Wong, S. H., Lui, R. N. and Sung, J. J. (2020). Covid‐19 and the digestive system. Journal of Gastroenterology Hepatology, 35(5), 744-748.

Worldmeter. (2021). COVID-19 Coronavirus Pandemic. Available at: https://www.worldometers.info/coronavirus/ . Accessed 02 May 2021.

Xing, J., Yin, X. and Chen, D. (2018). Rivaroxaban versus enoxaparin for the prevention of recurrent venous thromboembolism in patients with cancer: A meta-analysis. Medicine, 97(31), e11384-e11384.

Yavuz, S. and Ünal, S. (2020). Antiviral treatment of COVID-19. Turkish Journal of Medical Sciences, 50(SI-1), 611-619.

Yu, X. and Yang, R. (2020). COVID‐19 transmission through asymptomatic carriers is a challenge to containment. Influenza and Other Respiratory Viruses, 14(4), 474-475.

Zhai, P., Ding, Y., Wu, X., Long, J., Zhong, Y. and Li, Y. (2020). The epidemiology, diagnosis and treatment of COVID-19. International journal of antimicrobial agents, 55(5), 105955.

Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J. and Lu, R. (2020). A novel coronavirus from patients with pneumonia in China, 2019. New England Journal of Medicine, 382, 727-733.

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