Duaa Kamel Al- Moussawi¹, Huda Natiq Faris², Wesan Fadhel Khalef ²

¹Iraqi Ministry of Education Directorate of Education, Dhi Qar Governoratel Thi Qar, Iraq

²Department of Biology, College of Sciences, University of Thi Qar, Iraq

Received: May 3, 2023/ Revised: June 13, 2023/Accepted: June 20, 2023

(✉) Corresponding Author: Duua5174@gmail.com

Abstract

The proposal of novel drugs and approaches for effective treatment of the novel coronavirus is necessary after the quick outbreak of the disease. Since the commencement of the coronavirus spread, enormous efforts have been made to protect, alleviate, and cure the disease, though no specific treatment has been approved. Medicinal plant species can provide a solution as a source of natural antiviral compounds through the accumulation of secondary metabolites and lectins, as well as acting as a platform to express the viral immunogenic proteins. Several plant-derived anti-coronavirus compounds have been nominated that could be targeted for further research due to the similarity of the coronavirus disease in 2003 and the current coronavirus. This review considers plant species like Scutellaria baicalensis (Baikal skullcap) and Utrica dioica (stinging nettle) as viable candidates for the new coronavirus antiviral research. This paper examines the benefits and findings of earlier investigations into the novel coronavirus illness and earlier iterations of related corona viruses.

Keywords:  Novel drugs, Medicinal plant, Anti-coronavirus, Scutellaria baicalensis, Utrica dioica, Corona virus

References

Astuti, I. (2020). “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response.” Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14(4): 407-412.

Beyerstedt, S., E. B. Casaro and É. B. Rangel (2021). “COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection.” European Journal of Clinical Microbiology & Infectious Diseases 40: 905-919.

Clagett-Dame, M. and D. Knutson (2011). “Vitamin A in reproduction and development.” Nutrients 3(4): 385-428.

Croxtall, J. D. and C. M. Perry (2010). “Lopinavir/Ritonavir: a review of its use in the management of HIV-1 infection.” Drugs 70: 1885-1915.

Dhama, K., S. Khan, R. Tiwari, S. Sircar, S. Bhat, Y. S. Malik, K. P. Singh, W. Chaicumpa, D. K. Bonilla-Aldana and A. J. Rodriguez-Morales (2020). “Coronavirus disease 2019–COVID-19.” Clinical microbiology reviews 33(4): e00028-00020.

Gorbalenya, A. E., S. C. Baker, R. S. Baric, R. J. de Groot, C. Drosten, A. A. Gulyaeva, B. L. Haagmans, C. Lauber, A. M. Leontovich and B. W. Neuman (2020). “Severe acute respiratory syndrome-related coronavirus: The species and its viruses–a statement of the Coronavirus Study Group.” BioRxiv.

Hussain, M., S. K. Syed, M. Fatima, S. Shaukat, M. Saadullah, A. M. Alqahtani, T. Alqahtani, T. B. Emran, A. H. Alamri and M. Q. Barkat (2021). “Acute respiratory distress syndrome and COVID-19: a literature review.” Journal of Inflammation Research 14: 7225.

Lai, C.-C., T.-P. Shih, W.-C. Ko, H.-J. Tang and P.-R. Hsueh (2020). “Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.” International journal of antimicrobial agents 55(3): 105924.

Malone, B., N. Urakova, E. J. Snijder and E. A. Campbell (2022). “Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design.” Nature Reviews Molecular Cell Biology 23(1): 21-39.

McIntosh, K., M. S. Hirsch and A. Bloom (2021). “COVID-19: Epidemiology, virology, and prevention.” UpToDate. Available online: https://www. uptodate. com/contents/covid-19-epidemiology-virology-and-prevention (accessed on 18 March 2021).

Meng, L., F. Hua and Z. Bian (2020). “Coronavirus disease 2019 (COVID-19): emerging and future challenges for dental and oral medicine.” Journal of dental research 99(5): 481-487.

Montero-Odasso, M., S. Goens, N. Kamkar, R. Lam, K. Madden, F. Molnar, M. Speechley and S. Saverio (2020). “Canadian Geriatrics Society COVID-19 Recommendations for older adults–What do older adults need to know?” Canadian Geriatrics Journal 23(1): 149-151.

Nawrot, J., J. Gornowicz-Porowska, J. Budzianowski, G. Nowak, G. Schroeder and J. Kurczewska (2022). “Medicinal Herbs in the Relief of Neurological, Cardiovascular, and Respiratory Symptoms after COVID-19 Infection A Literature Review.” Cells 11(12): 1897.

Organization, W. H. (2020). “WHO Director-General’s opening remarks at the media briefing on COVID-19.” (No Title).

Pinotti, L., M. Manoni, L. Ferrari, M. Tretola, R. Cazzola and I. Givens (2021). “The contribution of dietary magnesium in farm animals and human nutrition.” Nutrients 13(2): 509.

Sakai, K., Y. Ami, M. Tahara, T. Kubota, M. Anraku, M. Abe, N. Nakajima, T. Sekizuka, K. Shirato and Y. Suzaki (2014). “The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.” Journal of virology 88(10): 5608-5616.

Samuels, E. and M. Kelly (2020). “How false hope spread about hydroxychloroquine to treat covid-19—and the consequences that followed.” Washington Post, April 13: 2020.

Schleicher, R. L., M. D. Carroll, E. S. Ford and D. A. Lacher (2009). “Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES).” The American journal of clinical nutrition 90(5): 1252-1263.

Schoeman, D. and B. C. Fielding (2019). “Coronavirus envelope protein: current knowledge.” Virology journal 16(1): 1-22.

Shahidi, F., A. C. C. Pinaffi-Langley, J. Fuentes, H. Speisky and A. C. de Camargo (2021). “Vitamin E as an essential micronutrient for human health: Common, novel, and unexplored dietary sources.” Free Radical Biology and Medicine 176: 312-321.

Shakoor, H., J. Feehan, A. S. Al Dhaheri, H. I. Ali, C. Platat, L. C. Ismail, V. Apostolopoulos and L. Stojanovska (2021). “Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19?” Maturitas 143: 1-9.

Sharifkashani, S., M. A. Bafrani, A. S. Khaboushan, M. Pirzadeh, A. Kheirandish, H. Yavarpour_Bali, A. Hessami, A. Saghazadeh and N. Rezaei (2020). “Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: potential therapeutic targeting.” European journal of pharmacology 884: 173455.

Slaton, N. A., R. J. Norman and C. E. Wilson Jr (2005). “Effect of Zinc Source and Application Time on Zinc Uptake and Grain Yield of Flood‐Irrigated Rice.” Agronomy Journal 97(1): 272-278.

Stadnytskyi, V., P. Anfinrud and A. Bax (2021). “Breathing, speaking, coughing or sneezing: What drives transmission of SARS‐CoV‐2?” Journal of Internal Medicine 290(5): 1010-1027.

Steardo Jr, L., L. Steardo and A. Verkhratsky (2020). “Psychiatric face of COVID-19.” Translational psychiatry 10(1): 261.

Upadhyay, M. and S. Gupta (2022). “Endoplasmic reticulum secretory pathway: Potential target against SARS-CoV-2.” Virus Research: 198897.

World Health Organization (2020). Transmission of SARS-CoV-2: implications for infection prevention precautions: scientific brief, 09 July 2020, World Health Organization.

Yadav, R., J. K. Chaudhary, N. Jain, P. K. Chaudhary, S. Khanra, P. Dhamija, A. Sharma, A. Kumar and S. Handu (2021). “Role of structural and non-structural proteins and therapeutic targets of SARS-CoV-2 for COVID-19.” Cells 10(4): 821.

Zimmerman, K. O., I. C. Akinboyo, M. A. Brookhart, A. E. Boutzoukas, K. A. McGann, M. J. Smith, G. Maradiaga Panayotti, S. C. Armstrong, H. Bristow and D. Parker (2021). “Incidence and secondary transmission of SARS-CoV-2 infections in schools.” Pediatrics 147(4).

How to cite this article

Al- Moussawi, D. K., Faris, H. N. and Khalef, W. F. (2023). Exploring the synergistic potential of natural plants as antiviral agents against COVID-19. Science Archives, Vol. 4(2), 170-177. https://doi.org/10.47587/SA.2023.4215

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