Atika Alahmed ✉¹, Eman Al-Rubaee² , and Talal H. Noon³
¹Department of Oral Medicine, College of Dentistry, University of Baghdad, Iraq
²Department of Basic Science, College of Dentistry, University of Baghdad, Iraq
³Department of Medicine, Al-Zahraa College of Medicine, University of Basra, Iraq
Received: May 18, 2023/ Revised: June 7, 2023/Accepted: June 15, 2023
(✉) Corresponding Author: atika.alahmed@gmail.com
Abstract
Galectins are a group of 16 members that all share an amino acid sequence named carbohydrate recognition domain that binds to a beta-galactoside and produces multiple intra- and extra-cellular functions such as modulating inflammation. Inflammatory bowel disease is a chronic inflammatory disorder of the large and small intestines that comprises two diseases, Crohn disease and Ulcerative Colitis. Ulcerative colitis showed a persistent inflammatory process that affects mainly the colon, this chronic colonic inflammation is affected by several internal and environmental factors. Many galectins are classically expressed in certain gut areas. Organ-specific distribution and abundance of some Galectins make them an important material for many researchers and a useful therapeutic target for different diseases, therefore; their role in colonic inflammation is reviewed to manifest their correlation to chronic diseases such as ulcerative colitis.
Keywords: Inflammatory Bowel Disease, Ulcerative Colitis, Galectins, Colonic Inflammation
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How to cite this article
Alahmed, A., Al-Rubaee, E. and Noon, T. H. (2023). Human Galectines and their contribution in the chronic colonic inflammation (review). Science Archives, Vol. 4(2), 141-146. https://doi.org/10.47587/SA.2023.4211
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