Mohamed Hafez
Alexander I. Popov, Valery N. Zelenkov, Tamara V. Teplyakova and Mohamed Rashad
1Department of Soil Science and Soil Ecology, Institute of Earth Sciences, Saint Petersburg State University, Embankment, 7/9, Saint Petersburg, 199034, Russia
2-Russian Research Institute of Vegetable Production 140153, Moscow, Russia
3-Laboratory of the State Scientific Center of Virology and Biotechnology “Vector” 30659, Novosibirsk, Russia
4-Land and Water Technologies Department, Arid Lands Cultivation Research Institute, City of Scientific Research and Technological Applications, New Borg El-Arab, 21934, Alexandria, Egypt.
Received: Aug 21, 2020 / Accepted: Sept 7, 2020/ Published: Sept 29, 2020
Abstract
The aim of this review was trying to access information to help the world in getting rid of a nightmare COVID-19, by evaluating the anti-virus activity of humic substances as natural anti-virus to inhibit COVID-19. In this scientific review, which devoted to biomedical aspects of various origin humic substances and other organic wastes influences on living organisms, is presented. It is shown that kinds of biological activity of humic substances (HS) are an integral indicator of properties of these substances. Data on humic substances and melanin of anti-viral, anti-carcinogen, and anti-virus diseases such as (COVID-19) activity is given too by immune-modulation. Humic substances, or humates, are the end points of organic (carbon-containing) degradation. They’re essentially what are left over from microbial decomposition of organisms and dead plant matter; however, they remain highly concentrated in minerals, amino acids, and fatty acids. Studies have shown that humic substances are effective against both naked and enveloped DNA viruses, including Coxsackie A9, influenza A and B, and herpes simplex type 1 and 2 viruses. In conclusion, humic substances effected on reduce oxidative stress and even induce apoptosis in hepatic cancer lines. humic substances are shown to also influence the micro-biome and possibly improve gut function. This will help make conclusive statements regarding humic substances function and its influence on immune-related diseases. The mechanism whereby humic substances inhibit the cytopathicity of a number of viruses has been studied in some depth. It is thought that the materials prevent viral replicating by sorbing onto the viral envelope protein and thereby blocking the sorption of viral particles to cell surfaces.
Keywords: Environmental- friendly, humic substances, biological activity and immune-modulation
How to cite this article:
Hafez, M., Popov, A.I., Zelenkov, V.N., Teplyakova, T.V. and Rashad, M. (2020) Humic substances as an environmental-friendly organic waste potentially help as natural anti-virus to inhibit Covid-19, Science Archives, Vol. 1 (2), 53-60.
Crossref DOI
http://dx.doi.org/10.47587/SA.2020.1202
Copyright
This is an open-access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
Babitskaya, V.G. (2002) Melanin complex from medicinal fungi Inonotusobliquus (Pers.:Fr.) Pilat (Chaga) (Aphyllophoromycetidae) // International J. of Medicinal Fungi, 4: 139-415.
Banaszkiewicz, W, Drobnik M. (1994) The influence of natural peat and isoletedhumic acid solution on certain indices of metabolism and of acid-base equilibrium in experimental animals // Rocz. Panstw. Zakl. Hig., 45: 353-360.
Belousov, M.V., Akhmedzhanov, R.R., Zykova, M.V. (2014a) Study of anti-hypoxic activity native humic acids of lowland peat of the Tomsk region // Chemical and Pharmaceutical Journal. Vol. 48: 29–31. https://doi.org/10.1080/001036277093667.
Belousov, M.V., Akhmedzhanov, R.R., Zykova, M.V. (2014b) Study of hepato-protective properties of native humic acids of lowland peat of Tomsk region // Chemical and Pharmaceutical Journal, 48 (4) 28–31.
Belousov, M.V., Akhmedzhanov, R.R., Zykova, M.V. (2014) Study of cardiotoxic properties of native humic acids of peat // Bulletin of Siberian medicine.13: 14–19.
Buzlama, AV, Chernov, YuN. (2010) Analysis of pharmacological properties, mechanisms of action and prospects for the use of humic substances in medicine // Experimental and clinical pharmacology. Vol. 73, No. 9: 43–48.https://doi.org/10.1080/00103622209366.
Clapp, C.E., Chen, Y., (2001) Hayes MHB, Cheng HH. Plant growth promoting activity of HS // Understanding and Managing Organic Matter in Soils, Sediments, and Waters / Eds. R.S. Swift and K.M. Sparks. Madison: IHSS, 54: 243–255.
Fedko, I.V. (2006) Chemical-pharmacological study of specific organic substances of peat / Abstract. Discand Pharmaceutical sciences. Tomsk, 24 :45-49.
Ghosal, S., Singh, S.K., Kumar, Y., Srivastava, R., Goel, R.K., Dey R,. (1988) Anti-ulcerogenic activity of fulvic acids and 4′‐methoxy‐6‐carbomethoxybiphenyl isolated from shilajit. Phytother Res; 2: 187-191
Gostishcheva, M.V. (2008) Chemical and pharmacological study of native humic acids of peat Tomsk region / Abstract. Disc and Pharmaceutical sciences, 24:12-18.
Ilycheva, T.N., Balakhnin, S.M., Gashnikova, N.M. (2014) Anti-viral Activity of Humic Substances // Third International Conference of CIS IHSS on Humic Innovative Technologies Tenth International Conference daRostim “Humic Substances and Other Biologically Active Compounds in Agriculture” HIT-daRostim-November 19–23, 2014, Lomonosov Moscow State University, Moscow, Russia. 42-45.https://doi.org/10.1080/001036277093
Ishiwatari, R. (1992) Macromolecular material (humic substance) in the water column and sediments. Mar Chem;39: 151-166.
Jiang, J.H. (2007) The anti-tumor activity and MDR reversal properties of constituents from Inonotusobliquus // Mikologiaifitopatologia. 41: 455-460.
Kahlos, K., Kangas, L., Hiltunen, R. (1987) Anti-tumor activity of some compounds and fractions from an N-hexane extract of Inonotusobliquus in vitro // Acta Pharm Fennica. 96: 33–40.
Khaziev, F.X., Gulko, A.E. (1990) Some properties humus peroxidase complex // Soil Science, 2: 30–36.
Kitapova, R.R., Ziganshin, A.U. (2015) Biological activity of humic substances obtained from peat and sapropel // Kazan Medical Journal. Т. 96. № 1: 84-89.https://doi.org/10.1080/001036277093667.
Klocking, R., Sprossig, M. (1972) Antiviral properties of humic acids. Cell Mol Life Sci; 28:607-8. 30.
Kornilayeva, G.V., Perminova, I.V., Gilyazova, A.V. (2010) Humic substances as promising Compounds for creating microbicidal preparations // Russian Immunological Journal. T. 4 (13), No. 3: 255–260.
Kovalevski, D.V., Perminova, I.V., Kudryavtsev, A.V., Petrosyan, V.S. (1996) A new approach to description of structure of HS and its application to estimating a quantitative structure – property relationship // the role of humic substance in the ecosystem and in environmental protection / Trans. 8th meeting of IHSS. Wroclav (Poland), 14:99-103.
Lishtvan, II., Kaputsky, N., Yanuta, Yu.G. (2004) Humic acids of peat and preparations on their basis // Environmental management. No. 10: 114–119.
Lordan, R., O’Keeffe, E., Tsoupras, A., Zabetakis, I. (2019) Total, Neutral, and Polar Lipids of Brewing Ingredients, By-Products and Beer: Evaluation of Antithrombotic Activities. Foods. 8, 171-180. https://doi.org/10.3390/foods8050171.
Loginov, W. (1962) Humo-Protein complex // Studies about Humus / Symp. Humus and Plant. 1961 / Eds. Acad S Prát and prof. V. Rypáček. Prague: Publishing House of the Czechoslovak Academy of Science, 135–141.
Malama, A.A., Bulanov, P.A. (1959) The effect of melanin on Ehrlich’s tumor // Dokl. A BSSR. 1965. V. 9, No. 9. P. 627–629. 18. Martynova E.Ya. Clinical observations of patients with cancer of the stomach, lungs, and esophagus stage IV with treatment of Chaga / Chaga and its therapeutic use in stage IV cancer. L.: MEDGIZ, 271–293.
Nardi, S., Pizzeghello, D., Muscolo, A., Vianello, A. (2002) Physiological effects of HS on higher plants – review // Soil Biol. Biochem. 34: 1527-1536.
Orlov, A.A. (2019) Examination of molecular space and feasible structures of bioactive components of humic substances by FTICR MS data mining in EMBL database. Scientific Reports. 56-65. doi.org/10.1038/s41598019 4800.
Ovchinnikova, T.F. (1991) The effect of humic preparation from peat on the proliferative activity and metabolism of yeast microorganisms // Humic substances in the biosphere. Doc, higher schools, Biol. Sciences. 10: 87–90.
Pii, Y., Mimmo, T., Tomasi, N., Terzano, R., Cesco, S., Crecchio, C. (2015a) Microbial interactions in the rhizosphere: beneficial influences of plant growth-promoting rhizobacteria on nutrient acquisition process. A review. Biol. Fertil. Soils.. 51, 403–415. https://doi.org/10.1007/s00374-015-0996-1
Popov, AI. (2004) Humic substances: properties, structure, education / Ed. E.I. Ermakova. SPbU: Publishing House of St. Petersburg. University, 248-260.
Rytik, P.G. (2007) Antiretroviral activity of some species of higher basidiomycetes // Russian journal AIDS, Cancer and Public Health, 11: 59–61.
Saito, B., Seckler, M.M. (2014) Alkaline extraction of humic substances from peat applied to organic-mineral fertilizer production. Braz J Chem Eng, 31: 675-82.
Schols, D., Wutzler, P., Klöcking, R., Helbig, B, De EC. (1991) Selective inhibitory activity of polyhydroxycarboxylates derived from phenolic compounds against human immunodeficiency virus replication. J Acquir Immune DeficSyndr; 4: 677-685.
Shashkina, M.Ya., Shashkin, P.N., Sergeev, A.V. (2005) Chaga in oncology // Russian Biotherapeutic Journal. 4: 59–72. https://doi.org/10.160/00103658709358
Sysoeva, M.A. (2004) Study of sol Chagi III. The influence of the composition of the raw materials on the yield of extractives of aqueous extracts Chaga // Chemistry of plant materials.4: 29–34.
Teplyakova, T., Gashnikova, N.M., Balakhnin, S.M., Kosogova, TA. (2012) Antiretroviral activity of extracts from chaga, melanin and humic compounds. Modern mycology in Russia // Materials of the 3rd congress of mycologists of Russia. T. 3. M.: National Academy of Mycology, 419-420.
Teplyakova, T.V., Gashnikova, N.M., Puchkova, LI. (2009) Type 1 human immunodeficiency virus reproduction inhibitor: Patent 237- 5073 C1 Rus. Federation. No. 2008124179/15; declared 06/11/2008; publ. 12/10/2009. Bull. No. 34. 14 p. https://doi.org/10.1080/00103627709366714
Teplyakova, T.V., Puchkova, L.I., Kosogova, T.A. (2013) Antiviral agent based on melanin: Patent 2480227 C2 Ros. Federation. No. 201112- 7305/15; declared 07/01/2011; publ. 04/27/2013. Bul. V 15: 12 -11.
Vasconcelos, M.T., Santos, S.D., Machado, APLMG. (1989) Evidence of conformational changes in fulvic acids from dialysis // Sci. Total Environ. V. 82: 489-499.
Visser, S.A. (1987) Effect of HS on mitochondrial respiration and oxidative phosphorylation // Sci. Tot. Environment. V. 62: 347–354.
World Health Organization (WHO). 2020–Novel Corona-virus (COVID-19 Situation). https://experience.arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd (2020).
Zhdanova, A.V. (2011) Study of structural components and physicochemical properties of humic substances of low mineralized silt sulphide mud as a source of antioxidant drugs / Abstract. Discand Pharmaceutical sciences. Samara, 24-31.
Rico, D., Martin-Diana, A.B., Barat, J.M., and Barry-Ryan, C. (2007). Extending and measuring the quality of fresh-cut fruit and vegetables: a review. Trends in Food Science & Technology, 18(7): 373-386.
Satishkumar, S. (2014) Studies on Jackfruit (Artocarpus heterophyllus Lam.) Chips production and its storage. M. Tech. (Agricultural Engineering), Thesis, University of Agricultural Sciences, Bangalore.
Shere, D.M., Kotapalle S.L., and Kulkarni, D.N. (1993) Effect of Maturity Stage on Qualities Fried Banana Chips. Journal of Maharashtra Agricultural Universities, 18(3): 338-338.
Shobha D, Bharati, P. (2010) Value addition to Ber (Zyziphus mauritiana Lam.) through preparation of pickle. Karnataka Journal of Agricultural Sciences, 20(2): 32-13.
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