Suhayla K. Mohammed ✉, Ebaa A. Hamooshy and Gulboy Abdolmajeed Nasir            

University of Baghdad College of agriculture, Al-Jadriya, Baghdad, Iraq

 (✉) Corresponding Author: suhayla_81@yahoo.com

Received: Aug 8, 2022/ Revised: Sept 4, 2022 / Accepted: Sept 6, 2022

Abstract

By using the deacetylation method, chitin is converted into bioproduct chitosan. Deacetylation can be accomplished using chemical or biological mechanisms. Due to its biocompatibility, nontoxicity, biodegradability, natural origin, and resemblance to human macromolecules, it is useful in medicine. Chitosan may have antibacterial and antioxidant properties. Additionally, it could be used in biotechnology, agriculture, gene therapy, food technology, medication delivery, cancer therapy, and other fields. The objective of the current review was to list the most significant applications of Chitosan in the biomedical field.

Keywords  Deacetylation, Antibacterial, Antioxidant, Biodegradability, Agriculture, Gene therapy

References

 Abedian, Z., Moghadamnia, A. A., Zabihi, E., Pourbagher, R., Ghasemi, M., Nouri, H. R. & Jenabian, N. (2019). Anticancer properties of chitosan against osteosarcoma, breast cancer, and cervical cancer cell lines. Caspian Journal of Internal Medicine10(4), 439. DOI: 10.22088/cjim.10.4.439.

Aldulimy, I. K., Shaker, A. H., & Al-dulaimi, F. K. (2021). Study of the effect of chitosan extracted from the mushroom on the experimentally induced hyperlipidemia in male rabbits. Iraqi Journal of Market Research and Consumer Protection13(2), 79-88. DOI: http://dx.doi.org/10.28936/jmracpc13.2.2021.

Avelelas, F., Horta, A., Pinto, L. F., Cotrim Marques, S., Marques Nunes, P., Pedrosa, R., & Leandro, S. M. (2019). Antifungal and antioxidant properties of chitosan polymers obtained from nontraditional Polybius henslowii sources. Marine drugs17(4), 239.

Babu, A., & Ramesh, R. (2017). Multifaceted applications of chitosan in cancer drug delivery and therapy. Marine drugs15(4), 96.

Chen, W., Wu, Q., Zhang, J., & Wu, H. (2008). Antibacterial mechanism of chitosan. Wei Sheng wu xue bao= Acta Microbiologica Sinica48(2), 164-168.

Dufes, C., Muller, J. M., Couet, W., Olivier, J. C., Uchegbu, I. F., & Schätzlein, A. G. (2004). Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles. Pharmaceutical research21(1), 101-107. https://doi.org/10.1023/B:PHAM.0000012156.65125.01

Gallo, M., Naviglio, D., Caruso, A. A., & Ferrara, L. (2016). Applications of chitosan as a functional food. In Novel approaches of nanotechnology in food (pp. 425-464). Academic Press. DOI: 10.1016/b978-0-12-804308-0.00013-3

Goy, R. C., Britto, D. D., & Assis, O. B. (2009). A review of the antimicrobial activity of chitosan. Polímeros19, 241-247. DOI: 10.1590/S0104-14282009000300013.

Hao, W., Li, K., Ma, Y., Li, R., Xing, R., Yu, H., & Li, P. (2021). Preparation and antioxidant activity of chitosan dimers with different sequences. Marine Drugs19(7), 366. https://doi.org/10.3390/md19070366

Hasegawa, M., Yagi, K., Iwakawa, S., & Hirai, M. (2001). Chitosan induces apoptosis via caspase‐3 activation in bladder tumor cells. Japanese journal of cancer research92(4), 459-466. https://doi.org/10.1111/j.1349-7006.2001.tb01116.x

Helander, I. M., Nurmiaho-Lassila, E. L., Ahvenainen, R., Rhoades, J., & Roller, S. (2001). Chitosan disrupts the barrier properties of the outer membrane of Gram-negative bacteria. International journal of food microbiology71(2-3), 235-244. https://doi.org/10.1016/S0168-1605(01)00609-2

kumar Kuppusamy, S., & Karuppaiah, J. (2013). In Vitro Evaluation of free radical scavenging activity of chitosan. Int. J. of Pharm. & Life Sci. (IJPLS)4(5), 2685-2690.

Kumar, M. R., Muzzarelli, R., Muzzarelli, C., Sashiwa, H., & Domb, A. J. (2004). Chitosan chemistry and pharmaceutical perspectives. Chemical reviews104(12), 6017-6084 https://doi.org/10.1021/cr030441b

Kurniasih, M., & Dewi, R. S. (2018, April). Toxicity tests, antioxidant activity, and antimicrobial activity of chitosan. In IOP Conference Series: Materials Science and Engineering (Vol. 349, No. 1, p. 012037). IOP Publishing. doi:10.1088/1757-899X/349/1/012037

Liu, J. N. (2008). Study on the hypolipidemic mechanism of chitosan. Doctor dissertation. Jiangnan university. Wuxi, China.

Mustafa, A. (2018). Pharmaceutical uses of chitosan in the medical field. European Journal of Medicine and Natural Sciences1(1), 1-6. DOI: https://doi.org/10.26417/ejis.v3i1.p35-40

Oksal, E., Pangestika, I., Muhammad, T. S. T., Mohamad, H., Amir, H., Kassim, M. N. I., & Andriani, Y. (2020). In vitro and in vivo studies of nanoparticles of chitosan-Pandanus tectorius fruit extract as a new alternative treatment for hypercholesterolemia via Scavenger Receptor Class B type 1 pathway. Saudi Pharmaceutical Journal28(10), 1263-1275. https://doi.org/10.1016/j.jsps.2020.08.017

Qi, L., Xu, Z., & Chen, M. (2007). In vitro and in vivo suppression of hepatocellular carcinoma growth by chitosan nanoparticles. European journal of cancer43(1), 184-193. https://doi.org/10.1016/j.ejca.2006.08.029

Rajalakshmi, A., Krithiga, N., & Jayachitra, A. (2013). Antioxidant activity of the chitosan extracted from shrimp exoskeleton. Middle East J. Sci. Res16(10), 1446-1451. DOI: 10.5829/idosi.mejsr.2013.16.10.12033

Rampino, A., Borgogna, M., Blasi, P., Bellich, B., & Cesàro, A. (2013). Chitosan nanoparticles: Preparation, size evolution and stability. International journal of pharmaceutics455(1-2), 219-228. https://doi.org/10.1016/j.ijpharm.2013.07.034.

Ramya, R., Venkatesan, J., Kim, S. K., & Sudha, P. N. (2012). Biomedical applications of chitosan: an overview. Journal of Biomaterials and Tissue Engineering2(2), 100-111. DOI: https://doi.org/10.1166/jbt.2012.1030

Reshad, R. A. I., Jishan, T. A., & Chowdhury, N. N. (2021). Chitosan and its broad applications: A brief review. Available at SSRN 3842055.  http://dx.doi.org/10.2139/ssrn.3842055

Rinaudo, M. (2006). Chitin and chitosan: Properties and applications. Progress in polymer science31(7), 603-632. https://doi.org/10.1016/j.progpolymsci.2006.06.001

Sahariah, P., & Másson, M. (2017). Antimicrobial chitosan and chitosan derivatives: a review of the structure-activity relationship. Biomacromolecules, 18(11),3846-3868. doi: 10.1021/acs.biomac.7b01058.

Takimoto, H., Hasegawa, M., Yagi, K., Nakamura, T., Sakaeda, T., & Hirai, M. (2004). Proapoptotic effect of a dietary supplement: water soluble chitosan activates caspase-8 and modulating death receptor expression. Drug metabolism and Pharmacokinetics19(1),76-82. https://doi.org/10.2133/dmpk.19.76

Xing, K., Zhu, X., Peng, X., & Qin, S. (2015). Chitosan antimicrobial and eliciting properties for pest control in agriculture: a review. Agronomy for Sustainable Development35(2), 569-588. DOI: 10.1007/s13593-014-0252-3

Zhang, S., Li, J., Li, J., Du, N., Li, D., Li, F., & Man, J. (2020). Application status and technical analysis of chitosan-based medical dressings: A review. RSC advances10(56), 34308-34322. DOI: 10.1039/D0RA05692H.

Zhao, D., Yu, S., Sun, B., Gao, S., Guo, S., & Zhao, K. (2018). Biomedical applications of chitosan and its derivative nanoparticles. Polymers10(4), 462. DOI: 10.3390/polym10040462. PMID: 30966497; PMCID: PMC6415442.

How to cite this article

Mohammed, S. K., Hamooshy, E. A., Nasir, G. A. (2022). Medical application of Chitosan. Science Archives, Vol. 3 (3), 224-227. https://doi.org/10.47587/SA.2022.3313

License                      Article Metadata

This work is licensed under a Creative Commons Attribution 4.0 International License.

View Details