Shaima Sh. AL-kilan and Ekhlas Abdallah Hassan✉
University of Diyala, Department of Chemistry, College of Science, Baquba, Diyala, Iraq
Received: June 19, 2023/ Revised: July 20, 2023/Accepted: July 22, 2023
(✉) Corresponding Author: ekhlasbiochemistry@gmail.com
Abstract
The aims of this study are the evaluation of serum Fibrinogen in preeclampsia and healthy controls; and the relation of Fibrinogen with hypertension. 90 subjects were incorporated in this study, 30 were healthy control with mean age 35.6 years. 60 Preeclampsia case with mean age 32-65 years preeclampsia, wherever all women were more 20 weeks of pregnancy. The blood was separated by centrifuge for evaluation coagulation profile levels and lipid profile. The findings were showed serum Fibrinogen was significantly decreased in preeclampsia than normal (p<0.01). A significant rise in diastolic blood pressure in preeclampsia group (p < 0.005), Systolic blood pressure was significantly varied among preeclampsia group (p < 0.001). Concerning the lipid profile, only TC was significantly increased in preeclampsia patients than control p < 0.0001 while no significant variations in lipid profile were observed between the two pregnant groups. The Fibrinogen is a good indicator for the detection of preeclampsia in pregnant women. New tests are needed for determining the concentration of Fibrinogen in the pregnancy stages.
Keywords: Preeclampsia, Pregnant Women, Fibrinogen.
References
Enquobahrie, D. A., Williams, M. A., Butler, C. L., Frederick, I. O., Miller, R. S., & Luthy, D. A. (2004). Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. American journal of hypertension, 17(7), 574-581.
Jain, S., Sharma, P., Kulshreshtha, S., Mohan, G., & Singh, S. (2010). The role of calcium, magnesium, and zinc in pre-eclampsia. Biological trace element research, 133, 162-170.
Kasperczyk, S., Kasperczyk, J., Ostałowska, A., Zalejska-Fiolka, J., Wielkoszyński, T., Świętochowska, E., & Birkner, E. (2009). The role of the antioxidant enzymes in erythrocytes in the development of arterial hypertension among humans exposed to lead. Biological trace element research, 130, 95-106.
MacKay, A. P., Berg, C. J., & Atrash, H. K. (2001). Pregnancy-related mortality from preeclampsia and eclampsia. Obstetrics & Gynecology, 97(4), 533-538.
Poon, L. C., Kametas, N. A., Pandeva, I., Valencia, C., & Nicolaides, K. H. (2008). Mean arterial pressure at 11+ 0 to 13+ 6 weeks in the prediction of preeclampsia. Hypertension, 51(4), 1027-1033.
Poon, L. C., Shennan, A., Hyett, J. A., Kapur, A., Hadar, E., Divakar, H., … & Hod, M. (2019). The International Federation of Gynecology and Obstetrics (FIGO) initiative on preeclampsia (PE): a pragmatic guide for first trimester screening and prevention. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 145(Suppl 1), 1.
Schjetlein, R., Haugen, G., & Wisløff, F. (1997). Markers of intravascular coagulation and fibrinolysis in preeclampsia: association with intrauterine growth retardation. Acta obstetricia et gynecologica Scandinavica, 76(6), 541-546.
Sibai, B., Dekker, G., & Kupferminc, M. (2005). Pre-eclampsia. The Lancet, 365(9461), 785-799.
Üstün, Y., Engin-Üstün, Y., & Kamacı, M. (2005). Association of fibrinogen and C-reactive protein with severity of preeclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 121(2), 154-158.
Wagner, L. K. (2004). Diagnosis and management of preeclampsia. American family physician, 70(12), 2317-2324.
Walker, J. J. (2000). Pre-eclampsia. The Lancet, 356(9237), 1260-1265.
Weinstein, L. (1982). Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. American journal of obstetrics and gynecology, 142(2), 159-167.
How to cite this article
AL-kilan, S. S. and Hassan, E. A. (2023). Plasma fibrinogen in preeclampsia pregnancy. Science Archives, Vol. 4(3), 208-212. https://doi.org/10.47587/SA.2023.4305
Licence Article Metadata
This work is licensed under a Creative Commons Attribution 4.0 International License.
