Yassmin A. Ramadan✉¹, Yasmeen O. Zhran ¹, Aziza A. Abdelfattah²,
Abubakr M. El-Mahmoudy¹
¹Department of Pharmacology, Benha University Faculty of Vet. Medicine, 13736 Moshtohor, Egypt.
²Department of Pathology, Benha University Faculty of Vet. Medicine, 13736 Moshtohor, Egypt
Received: May 30, 2023/ Revised: June 20, 2023/Accepted: June 23, 2023
(✉) Corresponding Author: yassminramadan80@gmail.com.
Abstract
Botanical medicine that fights the battle against various types of diseases not only in recent decades but also since the dawn of time, by using plant parts or plant as whole as it has low cost and lack of adverse effects. One of these plants that belongs to the Apocynaceae family is Vinca roseus which become widely distributed in tropical and subtropical areas. The aim of the present study was to investigate the phytochemical analysis of leaves of Vinca roseus growing in Egypt. Qualitative Phytochemical screening revealed the presence of Alkaloids, phenolics, Cardiac glycosides, Anthraquinone glycosides, Tannin, Flavonoids, Oils, Resins, Saponins and Protein. Gallic acid, Gums/Mucilages and Terpenoids were not noticeable. The results indicate that leaves extract of Vinca roseus can be used as a source of potential pharmaceutical agent especially in cancer.
Keywords: Antitumor Activity, Botanical Medicine, Phytochemical Constituents, Vinca roseus.
References
Adaikan, P., Gauthaman, K., & Prasad, R. (2001). History of herbal medicines with an insight on the pharmacological properties of Tribulus terrestris. The aging male, 4(3), 163-169.
Ali, S., Farooqui, N. A., Ahmad, S., Salman, M., & Mandal, S. (2021). Catharanthus roseus (sadabahar): a brief study on medicinal plant having different pharmacological activities. Plant Archives, 21(2), 556-559.
Almagro, L., Fernández-Pérez, F., & Pedreño, M. A. (2015). Indole alkaloids from Catharanthus roseus: bioproduction and their effect on human health. Molecules, 20(2), 2973-3000.
Arya, P., Singh, K., Sharma, D., Dhobi, M., Gupta, K. K., Singh, I. K., Kayesth, S. (2023). Herbal and traditional medicines pharmacovigilance for holistic treatment.
Aslam, J., Khan, S. H., Siddiqui, Z. H., Fatima, Z., Maqsood, M., Bhat, M. A. Khan, S. A. (2010). Catharanthus roseus (L.) G. Don. An important drug: it’s applications and production. Pharmacie Globale (IJCP), 4(12), 1-16.
Bandopadhyaya, S., Ramakrishnan, M., Thylur, R. P., & Shivanna, Y. (2015). In-vitro evaluation of plant extracts against colorectal cancer using HCT 116 cell line. Int J Plant Sci Ecol, 1(3), 107-112.
Chaachouay, N., Douira, A., & Zidane, L. (2022). Herbal medicine used in the treatment of human diseases in the Rif, Northern Morocco. Arabian Journal for Science and Engineering, 47(1), 131-153.
Chaturvedi, V., Goyal, S., Mukim, M., Meghani, M., Patwekar, F., Patwekar, M. Sharma, G. (2022). A Comprehensive Review on Catharanthus roseus L.(G.) Don: Clinical Pharmacology, Ethnopharmacology and Phytochemistry. J. Pharmacol. Res. Dev, 4, 17-36.
Ernst, E. (2005). The efficacy of herbal medicine–an overview. Fundamental & clinical pharmacology, 19(4), 405-409.
Evans, W., & Evans, D. (2002). Trease and Evans Pharmacognosy (15 ed.). Singapore: Sanders Co. Ltd.
Fabricant, D. S., & Farnsworth, N. R. (2001). The value of plants used in traditional medicine for drug discovery. Environmental health perspectives, 109(suppl 1), 69-75.
Farnsworth, N., Fong, H., Blomster, R., & Draus, F. (1962). Studies on Vinca major (apocynaceae) II: Phytochemical investigation. Journal of Pharmaceutical Sciences, 51(3), 217-224.
Gülçi˙ n, I. l., Beydemi˙ r, Ş., Topal, F., Gagua, N., Bakuridze, A., Bayram, R., & Gepdiremen, A. (2012). Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit. Journal of enzyme inhibition and medicinal chemistry, 27(4), 587-594.
Harborne, A. (1998). Phytochemical methods a guide to modern techniques of plant analysis: springer science & business media.
Harborne, J. (1973). Phytochemical methods, a guide to modern techniques of plant analysis, JB Harborne. Chapman. London. GB.
Havsteen, B. H. (2002). The biochemistry and medical significance of the flavonoids. Pharmacology & therapeutics, 96(2-3), 67-202.
Huang, W.-Y., Cai, Y.-Z., & Zhang, Y. (2009). Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutrition and cancer, 62(1), 1-20.
Jadhav, M. S., Malpure, P. S., Rajole, J. R., Nikam, U. D., & Ranade, K. R. (2023). Vinca (Catharanthus roseus) containing phytochemicals and pharmacological profile.
Jayaraj, A. J., Uchimahali, J., Gnanasundaram, T., & Thirumal, S. (2019). Evaluation of antimicrobial activity and phytochemicals analysis of whole plant extract of Vinca rosea. Evaluation, 12, 132-136.
Jequier, E. (1994). Carbohydrates as a source of energy. The American journal of clinical nutrition, 59(3), 682S-685S.
Kokate, C. K. (2008). Practical pharmacognosy. New Delhi, India: Vallabh Prakashan.
Krause, W. (2019). Resistance to anti-tubulin agents: From vinca alkaloids to epothilones. Cancer Drug Resistance, 2(1), 82.
Kyakulaga, A. H., Alinda, T. B., Vudriko, P., & Ogwang Engeu, P. (2011). In vivo antidiarrheal activity of the ethanolic leaf extract of Catharanthus roseus Linn. (Apocyanaceae) in Wistar rats.
Lahare, R. P., Yadav, H. S., Bisen, Y. K., & Dashahre, A. K. (2021). Estimation of total phenol, flavonoid, tannin and alkaloid content in different extracts of Catharanthus Roseus from Durg District, Chhattisgarh, India. Scholars Bulletin, 7(1), 1-6.
Leke, A. Z., Dolk, H., Loane, M., Casson, K., Maboh, N. M., Maeya, S. E. and Etiendem, D. (2022). Prevalence, determinants and attitude towards herbal medicine use in the first trimester of pregnancy in Cameroon: A survey in 20 hospitals. PLOS Global Public Health, 2(8), e0000726.
Li, F.-S., & Weng, J.-K. (2017). Demystifying traditional herbal medicine with modern approach. Nature plants, 3(8), 1-7.
Meuss, A. (2000). Herbal medicine. Curr. Sci, 78, 35-39.
Mukunthan, K., Elumalai, E., Patel, T. N., & Murty, V. R. (2011). Catharanthus roseus: a natural source for the synthesis of silver nanoparticles. Asian pacific journal of tropical biomedicine, 1(4), 270-274.
Naeem, M., Aftab, T., & Khan, M. M. A. (2017). Catharanthus roseus: Springer.
Nehete, J., Bhambar, R., Narkhede, M., & Gawali, S. (2013). Natural proteins: Sources, isolation, characterization and applications. Pharmacognosy reviews, 7(14), 107.
Newman, R. A., Yang, P., Pawlus, A. D., & Block, K. I. (2008). Cardiac glycosides as novel cancer therapeutic agents. Molecular interventions, 8(1), 36.
Obaid, H. H., Saqban, L. H., & Mohammed, L. Y. (2019). Cytotoxic Effect of Vinca rosea Aqueous Extracts on (L20B) Cell Line In Vitro. Indian Journal of Public Health Research & Development, 10(11).
Organization, W. H. (2005). National policy on traditional medicine and regulation of herbal medicines: Report of a WHO global survey: World Health Organization.
P Desbois, A. (2012). Potential applications of antimicrobial fatty acids in medicine, agriculture and other industries. Recent patents on anti-infective drug discovery, 7(2), 111-122.
Paarakh, M. P., Swathi, S., Taj, T., Tejashwini, V., & Tejashwini, B. (2019). Catharanthus Roseus Linn-a review. Acta Scientific Pharmaceutical Sciences, 3(10), 19-24.
Pizzi, A. (2021). Tannins medical/pharmacological and related applications: A critical review. Sustainable Chemistry and Pharmacy, 22, 100481.
Pranskuniene, Z., Balciunaite, R., Simaitiene, Z., & Bernatoniene, J. (2022). Herbal medicine uses for respiratory system disorders and possible trends in new herbal medicinal recipes during COVID-19 in pasvalys district, Lithuania. International Journal of Environmental Research and Public Health, 19(15), 8905.
Ramakrishnan, S. (2004). Textbook of medical biochemistry: Orient Blackswan.
Rasch, E., & SWIFT, H. (1960). Microphotometric analysis of the cytochemical Millon reaction. Journal of Histochemistry & Cytochemistry, 8(1), 4-17.
Renjini, K., Gopakumar, G., & Latha, M. (2017). The medicinal properties of phytochemicals in Catharanthus roseus-a review. Eur. J. Pharma. Med. Res, 4, 545-551.
Riaz, K., Rizvi, Z. F., Hyder, S., & Rashed, R. (2021). Antibacterial, antitumor activity and phytochemical studies of methanolic extract of (catharnthus roseu) (linn.) g. don. Pak J Bot, 53, 2259-2266.
Saha, A., Moitra, S., & Sanyal, T. (2022). Anticancer And Antidiabetic Potential of Phytochemicals Derived from Catharanthus roseus: A Key Emphasis to Vinca Alkaloids.
Schmidt, B., Ribnicky, D. M., Poulev, A., Logendra, S., Cefalu, W. T., & Raskin, I. (2008). A natural history of botanical therapeutics. Metabolism, 57, S3-S9.
Sharma, A., Shanker, C., Tyagi, L. K., Singh, M., & Rao, C. V. (2008). Herbal medicine for market potential in India: an overview. Acad J Plant Sci, 1(2), 26-36.
Sharma, K., Kaur, R., Kumar, S., Saini, R. K., Sharma, S., Pawde, S. V., & Kumar, V. (2023). Saponins: a concise review on food related aspects, applications and health implications. Food Chemistry Advances, 100191.
Shuaib, M., Ali, A., Ali, M., Panda, B. P., & Ahmad, M. I. (2013). Antibacterial activity of resin rich plant extracts. Journal of pharmacy & bioallied sciences, 5(4), 265.
Thaher, K. T. M. A. (2022). A Natural Anthraquinone Plants with Multi-Pharmacological Activities. Texas Journal of Medical Science, 10, 23-32.
Thomas, P. A., Williams-Woodward, J., Stegelin, F. E., & Pennisi, S. V. (2009). A guide for commercial production of vinca.
Verma, V., Sharma, S., Gaur, K., & Kumar, N. (2022). Role of vinca alkaloids and their derivatives in cancer therapy.
Vidhyalakshmi, S., & Gopalan, M. International Journal of Research Publication and Reviews. Journal homepage: www. ijrpr. com ISSN, 2582, 7421.
Whistler, R. L., & BeMiller, J. N. (1993). Industrial Gums: Polysaccharides and Their Derivatives (3rd ed.). UK: Academic Press.
Zhou, X.-J., & Rahmani, R. (1992). Preclinical and clinical pharmacology of vinca alkaloids. Drugs, 44(Suppl 4), 1-16.
How to cite this article
Ramadan, Y. A., Zhran, Y. O., Abdelfattah, A. A. and El-Mahmoudy, A. M. (2023). Preliminary phytochemical screening of Vinca roseus leaves. Science Archives, Vol. 4(2), 154-161. https://doi.org/10.47587/SA.2023.4213
Licence Article Metadata
This work is licensed under a Creative Commons Attribution 4.0 International License.
