Akeel Shamran Tushy
Department of Babylon Health, Imam Al-Sadiq Hospital, Laboratory of the Immunology Unit
Ministry of Health, Baghdad, Iraq
*Corresponding author: greetoop@gmail.com
Received: Mar 2, 2021 / Revised: April 26, 2021/ Accepted: May 19, 2021
Abstract
This study applied 120 clinical samples (40 plasma samples, 40 saliva samples, and 40 urine samples) from scabies patients and 20 healthy person samples as controls group, to determine the levels of prostaglandin E2 (PGE2) and Leukotriene B4 (LKB4) is a diagnostic parameter and evaluation its role and concentrations in the three samples and testing the best parameter that can be used to diagnose the scabies disease. This study showed that clinical samples especially urine of PGE2and saliva in LKB4 had a significant differentiation to another sample when compared to the control group. The levels of PGE2 in plasma samples were (409.9±184.3ug/ml, 29.1 St.E) and in saliva was (369±109 ug/ml, 17.3 St.E), in urine samples was (607.60±34.80ug/ml, 4.5 St.E) of patients group. While the level of PGE2 of control was (79±11.2ug/ml,3.5 St.E) in plasma and (79±11.2ug/ml,7.4St.E) in saliva samples, in urine samples was (162±43.5ug/ml,13.7St.E ), there noted the concentration of PGE2 in urine was increased when compared to control results, a while the levels of LKB4 in plasma samples was (322±149ug/ml,23.7St.E) and in saliva was (939±312 ug/ml, 49St.E), in urine samples was (79±11.2ug/ml,8.5 St.E) of patients group. while the level of PGE2 of control was (179±55ug/ml,17.6St.E) in plasma and (551±56ug/ml,18St.E)in saliva samples, in urine samples was (12.8±4.5ug/ml,1.4St.E ), there noted the concentration of LKB4 in saliva was increased when compared to control results, and in which can be used as laboratory samples to diagnose scabies, as they gave important differences with the other immune parameters. This study highlighted the importance of the new sample in terms of its role in diagnosed the disease compared to other clinical patient samples.
Keywords Salivary leukotriene B4, Urinary Prostaglandin E2, Scabies, Sarcoptes scabiei, Eicosanoids
Copyright
This is an open-access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
How to cite this article:
Tushy A.S. (2021). Salivary leukotriene B4 and urinary prostaglandin E2 levels: a novel diagnostic parameters tests for scabies disease. Science Archives, Vol. 2 (2), 68-74.http://dx.doi.org/10.47587/SA.2021.2201
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