Safaa Hussein Abdullah✉ and Adnan Issa Al-Badran
Department of Biology Collage of Science University of Basrah, Iraq
Received: Oct 20, 2022/ Revised: Nov 21, 2022/ Accepted: Nov 28, 2022
(✉) Corresponding Author: pgs2105@uobasrah.edu.iq
Abstract
Celiac disease is a chronic small intestinal inflammatory disease characterized by a lifelong reaction to dietary gluten in individuals with genetic predisposed. Many studies were suggests the presence of celiac disease predominance in women than man patients. This study was conducted in Thi-Qar province – south of Iraq. The blood samples were collected from healthy and celiac patients whose diagnosed by serology tests using Enzyme Linkage Immuno Sorbent Assay. The current study was designed to demonstrate women’s serologic parameters and their characters in Thi-Qar province. This case-control study demonstrates that women are predominantly incidence with celiac disease. Using the two-step testing is a quite precise strategy for diagnosing suspicious persons and can be a potent marker for monitoring celiac disease activity.
Keywords: Celiac disease, Anti-tTG, Anti-GA, Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value, Positive Likelihood Ratio and Negative Likelihood Ratio
References
Alaa, J. K. (2021). Evaluation of HLA-DQ2 and DQ8 haplotypes in patients with Celiac Disease Correlation with Circulating Anti-Tissue Transglutaminase and Anti- Gliadin Antibodies. Master dessirtation Submitted to the Council of the College of Medicine, University of Kerbala.
Al-Assaf, A. I., Ali, H. M., and Ad’hiah, A. H. (2021). Gene Expression of NLRP3 Inflammasome in Celiac Disease of Iraqi Children. Ibn AL-Haitham Journal For Pure and Applied Sciences,15(22). https://DOI.org/10.30526/2021.IHICPAS.2645.
Aldaghi, M. A., Dehghani, S. M., and Haghighat, M. (2016). Evaluation of the correlation between tTG-IgA titer and duodenal biopsy findings in children with suspected celiac disease. Iranian journal of pediatrics, 26(1). DOI: 10.5812/ijp.3615.
Al-Kazraji, K. (2009). Celiac disease: presentation with clinical and serological response. Med. J. Tikrit University, 2, 145.
Alshebani, A. M. and Abdalhamza, Z. S. (2018). The Role of celiac disease antibodies in the follow up of Patient on Gluten free diet. Revista Latinoamericana de Hipertension, 13(6), 561-566.
Al-Toma, A., Volta, U., Auricchio, R., Castillejo, G., Sanders, D. S., Cellier, C. and Lundin, K. E. (2019). European Society for the study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European gastroenterology journal, 7(5), 583-613. https://DOI.org/10.1177/2050640619844125.
Arif, H. S., Al-Hadithi, R. and Elah, S. A. (2009). Some Diagnostic Aspects of Celiac Disease in Iraqi children. Iraqi Journal of Medical Sciences, 32.
Brusca, I. (2015). Overview of biomarkers for diagnosis and monitoring of celiac disease. In Advances in Clinical Chemistry (1st ed., Vol. 68). Elsevier Inc. https://DOI.org/10.1016/bs.acc.2014.12.006.
Caio, G., Volta, U., Sapone, A., Leffler, D. A., De Giorgio, R., Catassi, C., and Fasano, A. (2019). Celiac disease: A comprehensive current review. BMC Medicine, 17(1), 1 – 20. https://DOI.org/10.1186/s12916-019-1380-z.
Dixit, R., Lebwohl, B., Ludvigsson, J. F., Lewis, S. K., Rizkalla-Reilly, N. and Green, P. H. (2014). Celiac disease is diagnosed less frequently in young adult men. Digestive diseases and sciences, 59(7), 1509-1512. https://DOI.org/10.1007/s10620-014-3025-6.
Fasano, A., and Catassi, C. (2001). Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology, 120(3), 636-651. https://DOI.org/10.1053/gast.2001.22123.
Fasano, A. and Catassi, C. (2012). Celiac disease. New England Journal of Medicine, 367(25), 2419-2426. DOI: 10.1056/NEJMcp1113994.
Green, P. H., and Cellier, C. (2007). Celiac disease. New england journal of medicine, 357(17), 1731-1743. DOI: 10.1056/NEJMra071600.
Husby, S., Koletzko, S., Korponay-Szabó, I., Kurppa, K., Mearin, M. L., Ribes-Koninckx, C. and Wessels, M. (2020). European Society Paediatric Gastroenterology, Hepatology and Nutrition guidelines for diagnosing coeliac disease 2020. Journal of pediatric gastroenterology and nutrition, 70(1), 141-156. DOI: 10.1097/MPG.0000000000002497.
Ibrahim, M. M. (2020). Prevalence of Celiac Disease among Cases of Irritable Bowel Syndrome in Baghdad, Iraq. Executive editor, 11(01), 1943. DOI: 10.37506/v11/i1/2020/ijphrd/194139.
Jansson-Knodell, C. L., Hujoel, I. A., West, C. P., Taneja, V., Prokop, L. J., Rubio-Tapia, A. and Murray, J. A. (2019). Sex difference in celiac disease in undiagnosed populations: a systematic review and meta-analysis. Clinical Gastroenterology and Hepatology, 17(10), 1954-1968. DOI:10.1016/j.cgh.2018.11.013.
Kuja-Halkola, R., Lebwohl, B., Halfvarson, J., Wijmenga, C., Magnusson, K., and Ludvigsson, J. (2016). Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twins. Gut, 65(11), 1793-1798. http://dx.DOI.org/10.1136/gutjnl-2016-311713.
Ludvigsson, J. F., Agreus, L., Ciacci, C., Crowe, S. E., Geller, M. G., Green, P. H. and Husby, S. (2016). Transition from childhood to adulthood in coeliac disease: the Prague consensus report. Gut, 65(8), 1242-1251. DOI: 10.1136/gutjnl-2017-313882.
Majeed, M. S. (2021). Correlation of Serum Soluble Interleukin-2 Receptor and Interleukin-18 with Auto-antibody Profile In Patients With Celiac Disease In Karbala Province (Doctoral thesis, University of Kerbala).
Mansour, A. A. and Najeeb, A. A. (2011). Coeliac disease in Iraqi type 1 diabetic patients. Arab Journal of Gastroenterology, 12(2), 103 – 105. https://DOI.org/10.1016/j.ajg.2011.04.007.
Mehrdad, M., Mansour-Ghanaei, F., Mohammadi, F., Joukar, F., Dodangeh, S. and Mansour-Ghanaei, R. (2012). Frequency of celiac disease in patients with hypothyroidism. Journal of thyroid research. https://DOI.org/10.1155/2012/201538.
Mohta, S. S., Rajput, M. S., Ahuja, C. V. and Makharia, G. K. (2021). Emergence of Celiac disease and Gluten-related disorders in Asia. Journal of Neurogastroenterology and Motility, 27(3), 337. DOI: 10.5056/jnm20140.
Quintero, O. L., Amador-Patarroyo, M. J., Montoya-Ortiz, G., Rojas-Villarraga, A., and Anaya, J. M. (2012). Autoimmune disease and gender: plausible mechanisms for the woman predominance of autoimmunity. Journal of autoimmunity, 38(2-3), J109-J119. https://DOI.org/10.1016/j.jaut.2011.10.003.
Rubio-Tapia, A., Hill, I. D., Kelly, C. P., Calderwood, A. H., and Murray, J. A. (2013). ACG clinical guidelines: diagnosis and management of celiac disease. Official journal of the American College of Gastroenterology| ACG, 108(5), 656-676. DOI: 10.1038/ajg.2013.79.
Shorouq, N. K. (2020). Association of HLA-DQ2, DQ8 and Immunological Markers with Especial Emphasis on IL-17A, with Celiac Disease. Southern Technical University. Master dessirtation.
Shreffler, J. (2022). Diagnostic Testing Accuracy: Sensitivity, Specificity, Predictive Values and Likelihood Ratios. https://www.statpearls.com/ArticleLibrary/viewarticle/96435#.
Singh, P., Arora, A., Strand, T. A., Leffler, D. A., Catassi, C., Green, P. H. and Makharia, G. K. (2018). Global prevalence of celiac disease: systematic review and meta-analysis. Clinical gastroenterology and hepatology, 16(6), 823 – 836. https://DOI.org/10.1016/j.cgh.2017.06.037.
Tye-Din, J. A., Galipeau, H. J., and Agardh, D. F. (2018). Celiac disease: a review of current concepts in pathogenesis, prevention, and novel therapies. Frontiers in pediatrics, 6, 350. DOI:10.3389/fped.2018.00350.
Werkstetter, K. J., Korponay-Szabo, I. R., Popp, A., Villanacci, V., Salemme, M., Heilig, G. and Sadat, A. T. E. (2017). Accuracy in diagnosis of celiac disease without biopsies in clinical practice. Gastroenterology, 153(4), 924-935.https://doi.org/10.1053/j.gastro.2017.06.002.
How to cite this article
Abdullah, S. H. and Al-Badran, A. I. (2022). Some immunological characteristics in Iraqi women with celiac disease. Science Archives, Vol. 3(4), 326-331. https://doi.org/10.47587/SA.2022.3412
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