Azza Ali Said,
Heba M. Kamel ✉and Noha I. Said
Zoology Department, Faculty of Science, Fayoum University, Fayoum, Egypt
Received: Jan 20, 2023/ Revised: Feb 20, 2023/ Accepted: Feb 22, 2023
(✉) Corresponding Author: Hmk11@fayom.edu.eg
Abstract
Resveratrol is a natural compound that exhibits many therapeutic properties including anti-inflammatory, antioxidant, and anticancer effects. Sulfoxaflor is a novel insecticide recently used in agriculture and pest control. The current study is an attempt to assess the vital role of resveratrol against sulfoxaflor-induced toxicity in the liver of adult male albino rats. Sixty adult male rats were randomly divided into six equal groups. In addition to the control group, one group received resveratrol alone (20 mg/kg). Two groups are treated with two selected doses of sulfoxaflor and two additional groups received combined treatment of resveratrol and sulfoxaflor. Treatment continued for four weeks. At the termination of the experiment, liver samples were collected for performing biochemical parameters. Liver function tests (serum ALT, AST, GGT, LDH, and albumin) and total antioxidants were also estimated. Histopathological studies, DNA fragmentation, and comet assay were performed. Our results indicated that, resveratrol reversed the significantly increased activities of antioxidant enzymes, albumin and decreased the levels of MDA, GSSG, NOx of SFX treated rats. It also ameliorated the serum levels of ALT, AST, GGT, and LDH. Histopathological lesions in liver tissues and DNA damage attributed to SFX administration were enhanced by resveratrol. Thus, resveratrol has been the interest of our study as it protects cells from the toxic effects of SFX and oxidative damage. In conclusion, resveratrol can be used as a therapeutic agent to counteract SFX toxic effects on the liver tissues through the modulation of the antioxidant defense mechanism.
Keywords: Sulfoxaflor, Resveratrol, Hepatotoxicity, Oxidative stress, Rat.
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How to cite this article
Said, A. A., Said, N. I. and Kamel, H. M. (2023). The effect of resveratrol against sulfoxaflor–induced hepatotoxicity in adult male rats. Science Archives, Vol. 4(1), 24-33. https://doi.org/10.47587/SA.2023.4105
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