Enass Waad Al-hadidi and Mahmoud Abduljabbar Altobji✉
Department. of Biology, College of Science, University of Mosul, Mosul, Iraq
✉ Corresponding Author: Enass.scp23@student.uomosul.edu.iq
Received: Aug 9, 2022/ Revised: Sept 1, 2022/ Accepted: Sept 23, 2022
Abstract
The factors that influence SARS-CoV-2 antibody development are currently unknown. This study aims to detect these factors in COVID-19 patients who have recovered. ELISA was used to measure IgG and IgM levels in 188 serum samples. The results showed that 94.03% of patients had IgG and 5.22% had IgM. IgG concentrations peaked at 6 months after infection, while IgM concentrations peaked at 8 months after infection. This study revealed that the fever, joint, and muscle discomfort had the greatest percentages of 75% and 27.9%, respectively, with a significant association with IgG. There is a correlation between IgM and conjunctivitis at P <0.01. IgG and IgM levels correlate with age (15-35years). The varied levels of IgG and IgM have a distinct and visible effect on the overall clinical symptoms, with or without a correlation. The understanding of several biological and serological factors in patients who have recovered may be useful in this effort.
Keywords COVID-19, anti-SARS-CoV-2 IgG, IgM
References
Abou-Ismail, M. Y., Diamond, A., Kapoor, S., Arafah, Y., and Nayak, L. (2020). The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management. Thrombosis Research, 194(6), 101–115. https://doi.org/10.1016/j.thromres.2020.06.029
Amir, E., Fatemeh, J., Neda, P., and Ali, A. (2020). Prevalence of Underlying Diseases in Hospitalized Pa- tients with COVID-19: a Systematic Review and Meta- Analysis. Archives of Academic Emergency Medicine, 8(1), e35–e35.
Amjadi, M. F., O’Connell, S. E., Armbrust, T., Mergaert, A. M., Narpala, S. R., Halfmann, P. J. et al. (2021). Fever, Diarrhea, and Severe Disease Correlate with High Persistent Antibody Levels against SARS-CoV-2. medRxiv.
Chen, W., Lan, Y., Yuan, X., Deng, X., Li, Y., Cai, X. et al. (2020). Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerging Microbes and Infections, 9(1), 469–473. https://doi.org/10.1080/22221751.2020.1732837
Dawood, A. (2022). Influence of SARS-CoV-2 Variants’ Spike Glycoprotein and RNA-Dependent RNA polymerase (Nsp12) Mutations on Remdesivir Docking Residues. Medical Immunology Russia, 2022; 24(3), 617-628. https://doi.org/10.15789/1563-0625-IOS-2486.
Fu, L., Wang, B., Yuan, T., Chen, X., Ao, Y., Fitzpatrick, T. et al. (2020). Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. Journal of Infection, 80(6), 656–665. https://doi.org/10.1016/j.jinf.2020.03.041.
Gorbalenya, A. E., Baker, S. C., Baric, R. S., de Groot, R. J., Drosten, C., Gulyaeva, A. A. et al. (2020). The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nature Microbiology, 5(4), 536–544. https://doi.org/10.1038/s41564-020-0695-z.
Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J. et al. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine, 382(18), 1708–1720. https://doi.org/10.1056/nejmoa2002032.
Hansen, B., Jarlhelt, I., Pérez-Alós, L., Hummelshøj L., Loftager, M., Rosbjerg, A. et al. (2021). SARS-CoV-2 Antibody Responses Are Correlated to Disease Severity in COVID-19 Convalescent Individuals. The Journal of Immunology, 206(1), 109–117. https://doi.org/10.4049/jimmunol.2000898.
Hu, Z., Li, J., Yang, C., Chen, F., Wang, Z., Lei, P. et al. (2021). Elevated SARS-Cov-2-Specific IgM Levels Indicate Clinically Unfavorable Outcomes in Patients with COVID-19: A Retrospective Cohort Study. International Journal of Genecology Medicine, 2021 Dec 29; 14:10429-10438. https://doi: 10.2147/IJGM.S322971.
Klein, S. L., Pekosz, A., Park, H. S., Ursin, R. L., Shapiro, J. R., Benner, S. E. et al. (2020). Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population. The Journal of clinical investigation, 130(11), 6141-6150.
Kumar, P.K., Banerjee, M., Bajpayee, A. et al. (2021). SARS-CoV-2 IgG Antibody and its Clinical Correlates in Convalescent Plasma Donors: An Indian Experience. Indian Journal of Clinical Biochemistry, https://doi.org/10.1007/s12291-021-01012-w.
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y. et al. (2020). Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia. New England Journal of Medicine, 382(13), 1199–1207.
Markmann, A. J., Giallourou, N., Bhowmik, D. R., Hou, Y. J., Lerner, A., Martinez, D. R. et al. (2021). Sex disparities and neutralizing-antibody durability to SARS-CoV-2 infection in convalescent individuals. Msphere, 6(4), e00275-21.
Minh, L. H. N., Abozaid, A. A. F., Ha, N. X., Le Quang, L., G, A. G., Tiwari, R. et al. (2021). Clinical and laboratory factors associated with coronavirus disease 2019 (Covid-19): A systematic review and meta-analysis. Reviews in Medical Virology, 31(6), 1–15. https://doi.org/10.1002/rmv.2288.
Ozturk, T., Howell, C., Benameur, K., Ramonell, R.P., Cashman, K. et al. (2020). Cross-sectional IgM and IgG profiles in SARS-CoV-2 infection. medRxiv, 2020 May 14:2020.05.10.20097535. https://doi: 10.1101/2020.05.10.20097535.
Sariol, A., and Perlman, S. (2020). Lessons for COVID-19 Immunity from Other Coronavirus Infections. Immunity, 53(2), 248–263. https://doi.org/10.1016/j.immuni.2020.07.005.
Stefanelli, P., Bella, A., Fedele, G., Pancheri, S., Leone, P., Vacca, P. et al. (2021). Prevalence of SARS-CoV-2 IgG antibodies in an area of northeastern Italy with a high incidence of COVID-19 cases: a population-based study. Clinical Microbiology and Infection, 27(4), 633.e1-633.e7. https://doi.org/10.1016/j.cmi.2020.11.013.
Tang, N., Li, D., Wang, X., and Sun, Z. (2020). Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. Journal of Thrombosis and Haemostasis, 18(4), 844–847. https://doi.org/10.1111/jth.14768.
Zhu, J., Ji, P., Pang, J., Zhong, Z., Li, H., He, C. et al. (2020). Clinical characteristics of 3062 COVID‐19 patients: a meta‐analysis. Journal of medical virology, 92(10), 1902-1914.
How to cite this article
Al-hadidi, E. W., Altobji, M. A. (2022). The Impact of IgG and IgM levels on clinical symptoms of people who have recovered from SARS-Cov-2. Science Archives, Vol. 3(3) 211-214.
CrossRef DOI: https://doi.org/10.47587/SA.2022.3310
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