Wedyan Yousif Al-tikrity and Thaer Mohamed Al-Mashhadani

 Department of Biology, College of Science, University of Mosul, Iraq

Received: Nov 2, 2022/ Revised: Dec 3, 2022/ Accepted: Dec 4, 2022

(✉) Corresponding Author: wedyan.20scp34@student.uomosul.edu.iq

Abstract

This study was done to find out the effect of the antioxidant Hydroxytoluene (BHT) on some physiological and histological variables of rats subjected to stress by starvation. 50 kg) starvation + BHT concentration (mg/kg 100) starvation + BHT concentration (50 mg/kg) starvation + olive oil). The data indicate that starvation decreases the sex hormones of rats exposed to stress by starvation Follicle Stimulating Hormone (FSH), Luteinizing Hormone(LH), Testosterone, and damage to testicular tissues, the antioxidant group BHT showed a concentration of (100,50 mg/kg) a protective effect against the negative effect of stress by starvation on sex hormones and testicular tissues by maintaining Its concentration is within its normal level, while the starvation group showed a negative effect on the concentration of sex hormones in the rats’ blood serum and testes tissue. The antioxidant BHT at concentrations of 50 and 100 mg/kg has an effective role in maintaining most of the physiological, biochemical, and histological variables from the negative effects of stress by starvation.

Keywords: BHT, Starvation, FSH, LH, Testosterone Hormone

References 

Abed, R. M. (2017). Effect of Olive Oil on Ibuprofen Induced Hepatorenal Toxicity in Rats. (Doctoral dissertation, University of Kerbala).

Al-Gharrawi, A. H., Al-Saadi, D. O., & Alasha, M. H. (2019). Effect of Starvation and Re-feeding on α–amylase Activity in Common Carp, CYPRINUS CARPIO L. Plant Archives, 19(1), 708-710.

Al-Hajj Hamid Ahmed (2010). “Optical Microscopic Preparations, Theory and Application.” Dar Al Masirah for Publishing, Distribution and Printing. First Edition, Amman – Jordan, p. 238.

Asadi, N., Bahmani, M., Kheradmand, A., & Rafieian-Kopaei, M. (2017). The Impact of Oxidative Stress on Testicular Function and the Role of Antioxidants in improving it: a review. Journal of clinical and diagnostic research: JCDR, 11(5), IE01.‏

Bancroft, J. D., & Stevens, A. (1975). Histopathological Stains and their Diagnostic Uses. Churchill

Livingstone.‏Basma, R. S., Suha, M. I. and Ahmed I. J. (2015). Detection and Determination of Butylated Hydroxyl toluene (BHT) in Imported Milk for Adults and Infants at Baghdad City. International J. Advanced Res., 3: 1178- 1185.

Bergendahl, M., Perheentupa, A., & Huhtaniemi, I. (1989). Effect of Short-term Starvation on Reproductive Hormone Gene Expression, Secretion and Receptor Levels in Male Rats. Journal of Endocrinology, 121(3), 409-417.

‏Fröhlich, E., & Wahl, R. (2022). Insight into Potential Interactions of Thyroid Hormones, Sex Hormones and Their Stimulating Hormones in the Development of Non-Alcoholic Fatty Liver Disease. Metabolites, 12(8), 718.

‏Gulcin, İ. (2020). Antioxidants and Antioxidant Methods: An updated overview. Archives of toxicology, 94(3), 651-715.‏

Hebebrand, J., Hildebrandt, T., Schlögl, H., Seitz, J., Denecke, S., Vieira, D. & Fulton, S. (2022). The role of Hypoleptinemia in the Psychological and Behavioral Adaptation to Starvation: implications for anorexia nervosa. Neuroscience & Biobehavioral Reviews, 104807.‏

Hosseinnia, E., Khara, H., Farokhroz, M., Yousefi Jourdehi, A., & Kazemi, R. (2021). Effects of Dietary Olive Oil and Butylated Hydroxytoluene (BHT) on Growth, Blood, and Immunity Indices in Juvenile Persian Sturgeon (Acipenser persicus).

Iranian Journal of Fisheries Sciences, 20(3), 810-827.‏Jacobs, E. C. (1948). Effects of Starvation on Sex Hormones in the Male. The Journal of Clinical Endocrinology, 8(3), 227-232.‏

Jalloud, Muntaha Mahmoud Al-Qattan (2016). The Stimulating Effect of Lemon Juice on the Total Capacity of Antioxidants and Male Hormones in Experimentally Fattened White Male New Zealand rabbits, Tikrit Journal of Pure Sciences 1662-1726:P12-18.

Janker and Khorshid (2009). Effect of Lipid Rancidity on Some Antioxidants in Male Rats, Tikrit Journal of Pure Sciences: 16626-1813: P116-108.

Jara, B., Merino, O., Sánchez, R., & Risopatrón, J. (2019). Positive Effect of Butylated Hydroxytoluene (BHT) on the Quality of Cryopreserved Cat Spermatozoa. Cryobiology, 89, 76-81.‏

Kamemura, N. (2018). Butylated Hydroxytoluene, a Food Additive, Modulates Membrane Potential and Increases the Susceptibility of Rat Thymocytes to Oxidative Stress. Computational Toxicology, 6, 32-38.‏

Karamichos, D., Escandon, P., Vasini, B., Nicholas, S. E., Van, L., Dang, D. H., … & Riaz, K. M. (2021). Anterior Pituitary, Sex Hormones, and Keratoconus: Beyond Traditional Targets. Progress in Retinal and Eye Research, 101016.

‏Liu, X., He, Y., Zhang, Q., Zeng, T., Zhang, J., Min, J., … & Hu, X. (2022). Catch‐up Fat in Male Adults Induces Low Testosterone and Consequently Promotes Metabolic Abnormalities and Cognitive Impairment. Andrology.

Parcheta, M., Świsłocka, R., Orzechowska, S., Akimowicz, M., Choińska, R., & Lewandowski, W. (2021). Recent Developments in Effective Antioxidants: The structure and antioxidant properties. Materials, 14(8), 1984.‏

Sakae, Y., & Tanaka, M. (2021). Metabolism and Sex Differentiation in Animals from a Starvation Perspective. Sexual Development, 15(1-3), 168-178.

‏Sales, C. F., Pinheiro, A. P. B., Ribeiro, Y. M., Weber, A. A., de Oliveira Paes-Leme, F., Luz, R. K., … & Melo, R. M. C. (2020). Effects of Starvation and Refeeding Cycles on Spermatogenesis and Sex Steroids in the Nile tilapia Oreochromis niloticus. Molecular and cellular endocrinology, 500, 110643.‏

Singh, A., Sharma, M., Prasad, S., Bhat, Y., Kumar, A., Pandey, D., & Shukla, S. K. Effect of Butylated Hydroxytoluene on Acrosome Integrity and Viability of Crossbred Bull Spermatozoa.

Soliman, M. M., Aldhahrani, A., Ghamry, H. I., Albogami, S., Youssef, G. B., Kesba, H., & Shukry, M. (2022). Chrysin Abrogates Gibberellic Acid‐induced Testicular Oxidative Stress and Dysfunction via the Regulation of Antioxidants and Steroidogenesis‐and Apoptosis‐Associated Genes. Journal of Food Biochemistry, e14165.

Steel, R. G. D. and Torrie, J. H. (1980).” Procedures of Statistics”, 2nd ed., McGraw-Hill Book Company.Inc., London.

How to cite this article

Al-Tikrity, W. Y. and Al-Mashhadani, T. M. (2022). Physiological and histological effects of the antioxidant butylated hydroxytoluene (BHT) on white male rats exposed to starvation stress. Science Archives, Vol. 3(4), 311-318. https://doi.org/10.47587/SA.2022.3410

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