Hawraa Aqel Abdulmonem and Hanaa Ali Aziz

 College of Science, Al-Muthanna Univ.,Iraq

Received: Oct 21, 2022/ Revised: Nov 11, 2022/ Accepted: Nov 17, 2022

(✉) Corresponding Author: hanabio-1983@mu.edu.iq

Abstract

Types 1 and 2 diabetes are predisposed to people with vitamin D deficiency, and immune cells and beta cells were found to include receptors for vitamin D’s activated form, 1 α, 25-dihydroxyvitamin D3. Type II diabetes was linked to vitamin D deficiency, which was proven to affect insulin synthesis and secretion in people and diabetes-prone animals. In addition, epidemiological research suggests a connection of the deficiency of vitamin D in adolescence with type I diabetes onset later in life. Various polymorphisms in vitamin D receptor genes have been linked to type I diabetes in certain groups. Pharmacological dosages of 1 α, 25-di-hydroxyvitamin D3, or its structural counterparts were proven in tests on nonobese diabetic mice to postpone the onset of diabetes, mostly by modulating the immune system. Thus, vitamin D deficiency could have an influence upon etiology of both types of diabetes, and a deeper comprehension of the underlying mechanisms might help create preventative measures.

 Keywords: 1,25(OH)2D3, Vitamin D deficiency, Beta cell, Diabetes Type 1,2

References

 Barrett-Connor, E., & Kritz-Silverstein, D. (1996). Does hyperinsulinemia preserve bone?. Diabetes care19(12), 1388-1392.

Baynes, K. C. R., Boucher, B. J., Feskens, E. J. M., & Kromhout, D. (1997). Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia40(3), 344-347.

Bell, N. H., Greene, A., Epstein, S., Oexmann, M. J., Shaw, S., & Shary, J. (1985). Evidence for alteration of the vitamin D-endocrine system in blacks. The Journal of clinical investigation76(2), 470-473.

Bikle, D. D. (1992). Clinical counterpoint: vitamin D: new actions, new analogs, new therapeutic potential. Endocrine reviews13(4), 765-784.

Borissova, A. M., Tankova, T., Kirilov, G., Dakovska, L., & Kovacheva, R. (2003). The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. International journal of clinical practice57(4), 258-261.

Boucher, B. J. (1998). Inadequate vitamin D status: does it contribute to the disorders comprising syndrome ‘X’?. British Journal of Nutrition79(4), 315-327.

Boucher, B. J., Mannan, N., Noonan, K., Hales, C. N., & Evans, S. J. W. (1995). Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia38(10), 1239-1245.

Bouillon, R., Garmyn, M., Verstuyf, A., Segaert, S., Casteels, K., & Mathieu, C. (1995). Paracrine role for calcitriol in the immune system and skin creates new therapeutic possibilities for vitamin D analogs. European journal of endocrinology133(1), 7-16.

Bouillon, R., Verstuyf, A., Verlinden, L., Eelen, G., & Mathieu, C. (2003). Prospects for vitamin D receptor modulators as candidate drugs for cancer and (auto) immune diseases. Vitamin D Analogs in Cancer Prevention and Therapy, 353-356.

Chertow, B. S., Sivitz, W. I., Baranetsky, N. G., Clark, S. A., Waite, A., & Deluca, H. F. (1983). Cellular mechanisms of insulin release: the effects of vitamin D deficiency and repletion on rat insulin secretion. Endocrinology113(4), 1511-1518.

Chiu, K. C., Chu, A., Go, V. L. W., & Saad, M. F. (2004). Hypovitaminosis D is associated with insulin resistance and β cell dysfunction. The American journal of clinical nutrition79(5), 820-825.

Chiu, K. C., Chuang, L. M., & Yoon, C. (2001). The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Medical Genetics2(1), 1-8.

Cosman, F., Morgan, D. C., Nieves, J. W., Shen, V., Luckey, M. M., Dempster, D. W. & Parisien, M. (1997). Resistance to bone resorbing effects of PTH in black women. Journal of Bone and Mineral Research12(6), 958-966.

D’Ambrosio, D., Cippitelli, M., Cocciolo, M. G., Mazzeo, D., Di Lucia, P., Lang, R., & Panina-Bordignon, P. (1998). Inhibition of IL-12 production by 1, 25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. The Journal of clinical investigation101(1), 252-262.

Deluca, H. F., & Cantorna, M. T. (2001). Vitamin D: Its role and uses in immunology 1. The FASEB journal15(14), 2579-2585.

Eurodiab Substudy 2 Study Group. (1999). Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. Diabetologia, 42(1), 51-54.

Fronczak, C. M., Barón, A. E., Chase, H. P., Ross, C., Brady, H. L., Hoffman, M., & Norris, J. M. (2003). In utero dietary exposures and risk of islet autoimmunity in children. Diabetes care26(12), 3237-3242.

Fukunaga, Y., Minamikawa, J., Inoue, D., & Koshiyama, H. (1997). Does insulin use increase bone mineral density in patients with non—insulin-dependent diabetes mellitus?. Archives of internal medicine157(22), 2668-2669.

Gedik, O., & Akahn, S. (1986). Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia29(3), 142-145.

Giulietti, A., Gysemans, C., Stoffels, K., van Etten, E., Decallonne, B., Overbergh, L., … & Mathieu, C. (2004). Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice. Diabetologia47(3), 451-462.

Gregori, S., Giarratana, N., Smiroldo, S., Uskokovic, M., & Adorini, L. (2002). A 1α, 25-dihydroxyvitamin D3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes51(5), 1367-1374.

Hanaa, A. A. and Dhay, A. (2020). Vitamin D deficiency: A review of the relationship between vitamin D Deficiencies with Some Disease as Obesity, Diabetes and Cardiovascular in Al-Muthanna Province – Iraq. International Journal of Psychosocial Rehabilitation, 24(9),1475-7192.

Haussler, M. R., Whitfield, G. K., Haussler, C. A., Hsieh, J. C., Thompson, P., Selznick, S. H., … & Jurutka, P. W. (1998). The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. Journal of bone and mineral research13(3), 325-349.

Holick, M. F. (2002). Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health. Current Opinion in Endocrinology, Diabetes and Obesity9(1), 87-98.

Holick, M. F. (2003). A millenium perspective Vitamin D. J Cell Biochem88(2), 296-307.

Holick, M. F. (2004). Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. The American journal of clinical nutrition80(6), 1678S-1688S.

 Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M. R., & Virtanen, S. M. (2001). Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. The Lancet358(9292), 1500-1503.

Inaba, M., Nishizawa, Y., Mita, K., Kumeda, Y., Emoto, M., Kawagishi, T., & Morii, H. (1999). Poor glycemic control impairs the response of biochemical parameters of bone formation and resorption to exogenous 1, 25-dihydroxyvitamin D3 in patients with type 2 diabetes. Osteoporosis International9(6), 525-531.

Inomata, S., Kadowaki, S., Yamatani, T., Fukase, M., & Fujita, T. (1986). Effect of 1 alpha (OH)-vitamin D3 on insulin secretion in diabetes mellitus. Bone and mineral1(3), 187-192.

Isaia, G., Giorgino, R., & Adami, S. (2001). High prevalence of hypovitaminosis D in female type 2 diabetic population. Diabetes care24(8), 1496-1496.

Ishida, H., Seino, Y., Matsukura, S., Ikeda, M., Yawata, M., Yamashita, G., … & Imura, H. (1985). Diabetic osteopenia and circulating levels of vitamin D metabolites in type 2 (noninsulin-dependent) diabetes. Metabolism34(9), 797-801.

Ismail, A., & Namala, R. (2000). Impaired glucose tolerance in vitamin D deficiency can be corrected by calcium. The Journal of nutritional biochemistry11(3), 170-175.

Iyengar, S., Hamman, R. F., Marshall, J. A., Majumder, P. P., Ferrell, R. E., Rao, D. C., & Vogler, G. P. (1989). On the role of vitamin D binding globulin in glucose homeostasis: results from the San Luis Valley Diabetes Study. Genetic epidemiology6(6), 691-698.

Johnson, J. A., Grande, J. P., Roche, P. C., & Kumar, R. (1994). Immunohistochemical localization of the 1, 25 (OH) 2D3 receptor and calbindin D28k in human and rat pancreas. American Journal of Physiology-Endocrinology and Metabolism267(3), E356-E360.

Kadowaki, S., & Norman, A. W. (1984). Dietary vitamin D is essential for normal insulin secretion from the perfused rat pancreas. The Journal of clinical investigation73(3), 759-766.

Karvonen, M., Jäntti, V., Muntoni, S., Stabilini, M., Stabilini, L., Muntoni, S., & Tuomilehto, J. (1998). Comparison of the seasonal pattern in the clinical onset of IDDM in Finland and Sardinia. Diabetes care21(7), 1101-1109.

Lee, S., Clark, S. A., Gill, R. K., & Christakos, S. (1994). 1, 25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretion. Endocrinology134(4), 1602-1610.

Luong, K. V. Q., Nguyen, L. T. H., & Pham Nguyen, D. N. (2005). The role of vitamin D in protecting type 1 diabetes mellitus. Diabetes/metabolism research and reviews21(4), 338-346.

Mathieu, C., Gysemans, C. and Guilietti, A. (2005). Vitamin D and diabetes. Di-abetologia. 48: 1247–1257.

Mathieu, C., Laureys, J. and Sobis, H. (1992). 1,25-Dihydroxyvitamin D3 pre-vents insulitis in NOD mice. Diabetes. 41: 1491–1495

Mathieu, C., van Etten, E., Decallonne, B., Guilietti, A., Gysemans, C., Bouillon, R., & Overbergh, L. (2004). Vitamin D and 1, 25-dihydroxyvitamin D3 as modulators in the immune system. The Journal of steroid biochemistry and molecular biology89, 449-452.

Mathieu, C., van Etten, E., Gysemans, C., Decallonne, B., & Bouillon, R. (2002). Seasonality of birth in patients with type 1 diabetes. The Lancet359(9313), 1248.

Mathieu, C., Van Etten, E., Gysemans, C., Decallonne, B., Kato, S., Laureys, J., & Bouillon, R. (2001). In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice. Journal of Bone and Mineral Research16(11), 2057-2065.

Mathieu, C., Waer, M., Laureys, J., Rutgeerts, O., & Bouillon, R. (1994). Prevention of autoimmune diabetes in NOD mice by 1, 25 dihydroxyvitamin D3. Diabetologia37(6), 552-558.

McDermott, M. F., Ramachandran, A., Ogunkolade, B. W., Aganna, E., Curtis, D., Boucher, B. J., & Hitman, G. A. (1997). Allelic variation in the vitamin D receptor influences susceptibility to IDDM in Indian Asians. Diabetologia40(8), 971-975.

Morrissey, R. L., Bucci, T. J., Empson Jr, R. N., & Lufkin, E. G. (1975). Calcium-binding protein: its cellular localization in jejunum, kidney and pancreas. Proceedings of the Society for Experimental Biology and Medicine149(1), 56-60.

Motohashi, Y., Yamada, S., Yanagawa, T., Maruyama, T., Suzuki, R., Niino, M., & Saruta, T. (2003). Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetes. The Journal of Clinical Endocrinology & Metabolism88(7), 3137-3140.

Nejentsev, S., Cooper, J. D., Godfrey, L., Howson, J. M., Rance, H., Nutland, S., & Todd, J. A. (2004). Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes. Diabetes53(10), 2709-2712.

Norman, A. W., Frankel, B. J., Heldt, A. M., & Grodsky, G. M. (1980). Vitamin D deficiency inhibits pancreatic secretion of insulin. Science209(4458), 823-825.

Nyomba, B. L., Bouillon, R., LISSENS, W., BAELEN, H. V., & MOOR, P. D. (1985). 1, 25-Dihydroxyvitamin D and vitamin D-binding protein are both decreased in streptozotocin-diabetic rats. Endocrinology116(6), 2483-2488.

Ogunkolade, B. W., Boucher, B. J., Prahl, J. M., Bustin, S. A., Burrin, J. M., Noonan, K., & Hitman, G. A. (2002). Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes51(7), 2294-2300.

Ortlepp, J. R., Metrikat, J., Albrecht, M., Von Korff, A., Hanrath, P., & Hoffmann, R. (2003). The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men. Diabetic Medicine20(6), 451-454.

Pratley, R. E., Thompson, D. B., Prochazka, M., Baier, L., Mott, D., Ravussin, E., & Bogardus, C. (1998). An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. The Journal of clinical investigation101(8), 1757-1764.

Scragg, R., Holdaway, I., Singh, V., Metcalf, P., Baker, J., & Dryson, E. (1995). Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes research and clinical practice27(3), 181-188.

Scragg, R., Sowers, M., & Bell, C. (2004). Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes care27(12), 2813-2818.

Sergeev, I. N., & Rhoten, W. B. (1995). 1, 25-Dihydroxyvitamin D3 evokes oscillations of intracellular calcium in a pancreatic beta-cell line. Endocrinology136(7), 2852-2861.

 Shires, R., Teitelbaum, S. L., Bergfeld, M. A., Fallon, M. D., Slatopolsky, E., & Avioli, L. V. (1981). The effect of streptozotocin-induced chronic diabetes mellitus on bone and mineral homeostasis in the rat. The Journal of laboratory and clinical medicine97(2), 231-240.

Stene, L. C., Joner, G., & Norwegian Childhood Diabetes Study Group. (2003). Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. The American journal of clinical nutrition78(6), 1128-1134.

Stene, L. C., Ulriksen, J., Magnus, P., & Joner, G. (2000). Use of cod liver oil during pregnancy associated with lower risk of Type I diabetes in the offspring. Diabetologia43(9), 1093-1098.

Taylor, A. V., & Wise, P. H. (1998). Vitamin D replacement in Asians with diabetes may increase insulin resistance. Postgraduate medical journal74(872), 365-366.

van Daele, P. L., Stolk, R. P., Burger, H., Algra, D., Grobbee, D. E., Hofman, A., & Pols, H. A. (1995). Bone density in non-insulin-dependent diabetes mellitus: the Rotterdam Study. Annals of internal medicine122(6), 409-414.

van Halteren, A. G., van Etten, E., de Jong, E. C., Bouillon, R., Roep, B. O., & Mathieu, C. (2002). Redirection of human autoreactive T-cells upon interaction with dendritic cells modulated by TX527, an analog of 1, 25 dihydroxyvitamin D3. Diabetes51(7), 2119-2125.

Wareham, N. J., Byrne, C. D., Carr, C., Day, N. E., Boucher, B. J., & Hales, C. N. (1997). Glucose intolerance is associated with altered calcium homeostasis: a possible link between increased serum calcium concentration and cardiovascular disease mortality. Metabolism46(10), 1171-1177.

Zeitz, U., Weber, K., Soegiarto, D. W., Wolf, E., Balling, R., & Erben, R. G. (2003). Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. The FASEB journal17(3), 1-14.

Zella, J. B., & DeLuca, H. F. (2003). Vitamin D and autoimmune diabetes. Journal of cellular biochemistry88(2), 216-222.

Zella, J. B., McCary, L. C., & DeLuca, H. F. (2003). Oral administration of 1, 25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus. Archives of biochemistry and biophysics417(1), 77-80.

Zittermann, A. (2003). Vitamin D in preventive medicine: are we ignoring the evidence? British Journal of Nutrition89(5), 552-572.

How to cite this article

Abdulmonem, H. A., Aziz, H. A. (2022). A review: The relationship between vitamin D deficiency and diabetes Type 1,2. Science Archives, Vol. 3(4), 319-325 https://doi.org/10.47587/SA.2022.3411

Licence                  Article Metadata

This work is licensed under a Creative Commons Attribution 4.0 International License.

 

View Details