Nadia Khalid Mustafa✉ and Sahar Salim Al-Nakkar
Department of Biology, College of Science, University of Mosul, Mosul, Iraq
Received: Dec 30, 2022/ Accepted: Jan 19, 2023/ Published: Jan 28, 2023
(✉) Corresponding Author: nadia20scp77@student.uomosul.edu.iq
Abstract
Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease involving multiple organ systems. This study aims to identify uncommon bacteria like Pseudomonas luteola as a human pathogen isolate from systemic lupus erythematosus patients in Mosul. This study involved 60 SLE patients who had been diagnosed at Ibn-Sena Educational Hospital in Mosul City from November 2021 to April 2022. Blood and MacConkey agar have been used to culture the samples. 55 samples (91.7%) showed positive results (grew the bacteria). We identified one Pseudomonas luteola 1.81% from positive growth of urine culture. It was identified by the biochemical test, API E20, and Vitek-2 system and had its identification verified using 16S rRNA-based molecular methods. The bacteria were resistant to meropenem, ceftriaxone, cefotaxime, gentamycin, doxycycline, ciprofloxacin, and trimethoprim, while they had sensitive to levofloxacin.
Keywords: Systemic Lupus Erythematosus, Pseudomonas luteola
References
Alhalimi, A. A., AlShammari, L. T., Al-Qurayn, A. K., & Al Rashed, A. S. (2022). Infective Endocarditis Caused by Pseudomonas luteola in a Pediatric Patient. A Case Report and Review of Literature. The American Journal of case reports, 23, e935743. https://doi.org/10.12659/AJCR.935743.
Barry, M. (2021). Pseudomonas luteola Bacteremia in Newly Diagnosed Systemic Lupus Erythematosus. Case Reports in Infectious Diseases, 2021.
Ben Hmida, S., Boughariou, I., Gassara, F., Maazoun, M., Eleuch, E., Marrakchi, C. & Ben Jmeaa, M. (2021). Pseudomonas Luteola Infection: First Case Report of Urinary Tract Infection and Review of Literature. Electron J Gen Med. 18(5), pg.313.
Chihab, W., Alaoui, A. S., & Amar, M. (2004). Chryseomonas luteola identified as the source of serious infections in a Moroccan University Hospital. Journal of clinical microbiology, 42(4), 1837–1839. https://doi.org/10.1128/JCM.42.4.1837-1839.2004.
Czajkowski, K., Broś-Konopielko, M., & Teliga-Czajkowska, J. (2021). Urinary tract infection in women. Przeglad menopauzalny Menopause review, 20(1), 40–47. https://doi.org/10.5114/pm.2021.105382
Gaschet, A., Engrand, C., Piau, C. (2009) Multiple brain abscesses caused by Pseudomonas luteola. Pediatr Infect Dis J. 2009;28(12):1144–1146.
Dima, A., Balaban, D. V., Jurcut, C., & Jinga, M. (2021). Systemic lupus erythematosus-related acute pancreatitis. Lupus, 30(1), 5–14. https://doi.org/10.1177/0961203320978515.
Dorgham, D. A., Anwar, S. & Al Shimaa, K. (2021). Infection in systemic lupus erythematosus patients. The Egyptian Rheumatologist. 43(2): 115-118.
El-Raouf, A., Mona, A., Mohamed, N. A., Abdel-Latif, G. M., Mohamed, S. R., & Mohamed, M. M. (2020). Detection of Bacterial Infection in Systemic Lupus Erythematosus Patients and their Antibacterial Susceptibility Pattern in Mansoura University Hospital. Egyptian Journal of Medical Microbiology. 29(1): 43-50.
Hasan, T. H., Al-Harmoosh, R. A. (2020). Mechanisms of antibiotics resistance in bacteria. System. Rev. in Pharm., 11(6), 817-823.
La Paglia, G. M. C., Leone, M. C. and Lepri, G. (2017). systemic lupus erythematosus. Clin Exp Rheumatol, 35:551–61.
Li, Z., Xiao, Y., & Zhang, L. (2020). Application of procalcitonin, white blood cell count and neutrophil-to-lymphocyte ratio in the diagnosis of systemic lupus erythematosus with a bacterial infection. Ann Palliat Med. 9(6): 3870-3876.
Otto, M. P., Foucher, B., Dardare, E., Gérôme, P. Severe catheter related bacteremia due to Pseudomonas luteola. Med Mal Infect, 43(4):170-71.
Petri, M., Orbai, A. M., Alarcón, G. S., Gordon, C., Merrill, J. T., Fortin, P. R., Bruce, I. N., Isenberg, D., Wallace, D. J., Nived, O., Sturfelt, G., Ramsey-Goldman, R., Bae, S. C., Hanly, J. G., Sánchez-Guerrero, J., Clarke, A., Aranow, C., Manzi, S., Urowitz, M., Gladman, D., Magder, L. S. (2012). Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis and rheumatism, 64(8), 2677–2686.
Sambrook, J. and Russell, D. W. (2001). Molecular Cloning: A Laboratory Manual. 3rd Edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
Santos, A. L., Dos Santos, A. P., Ito, C., Queiroz, P., de Almeida, J. A., de Carvalho Júnior, M., de Oliveira, C. Z., Avelino, M., Wastowski, I. J., Gomes, G., Souza, A., Vasconcelos, L., Santos, M, O., da Silva, C. A., Carneiro, L. C. (2020). Profile of enterobacteria resistant to Beta-lactams. Antibiotics, 9(7), 410.
Stojan, G., & Petri, M. (2018). Epidemiology of systemic lupus erythematosus: an update. Current opinion in rheumatology, 30(2), 144–150. https://doi.org/10.1097/BOR.0000000000000480
Sweeney, M. T., Lubbers, B. V., Schwarz, S., Watts, J. L. (2018). Applying definitions for multidrug resistance, extensive drug resistance, and pan drug resistance to clinically significant livestock and companion animal bacterial pathogens. J. Antimicrob. Chemother., 73(6), 1460-1463.
Tsang-A-Sjoe, M. W. P., & Bultink, I. E. M. (2021). New developments in systemic lupus erythematosus. Rheumatology (Oxford, England), 60(Suppl 6), vi21–vi28. https://doi.org/10.1093/rheumatology/keab498.
Wen, A. Y., Weiss, I. K., Kelly, R. B. (2013). Chryseomonas luteola bloodstream infection in a pediatric patient with pulmonary arterial hypertension receiving intravenous treprostinil therapy. Infection., 41(3):719-22.
Wyre, N. R. (2020). Emerging Zoonotic Diseases in Ferrets. The veterinary clinics of North America. Exotic animal practice, 23(2), 299–308. https://doi.org/10.1016/j.cvex.2020.01.012.
How to cite this article
Mustafa, N. K. and Al-Nakkar, S. S. (2023). Detection and Identification of Pseudomonas luteola as Newly Diagnosis Systemic Lupus Erythematosis in Mosul city, Iraq. Science Archives, Vol. 4(1), 18-21. https://doi.org/10.47587/SA.2023.4104
Licence Article Metadata
This work is licensed under a Creative Commons Attribution 4.0 International License.