Monobactams as anticancer : a review study

 Ahmed A. J. Mahmood

 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq                                 ahmedsot@gmail.com

Received: Dec 4, 2021 / Revised: Jan 15, 2022/ Accepted: Jan 20, 2022

Abstract

Cancer is a heterogeneous disease which categories as the second-leading cause of death worldwide. It is fatal to 42% of diagnosed patients every year. The ideal anticancer agents needed to be powerful, well-tolerated in patients, with low side effects and high selectivity. Antibiotics on the other hand are efficient, well-tolerated, with a very low level of toxicity. Therefore, they continue to be the most important goal for new drugs invention. 2-Azetidinones (β-lactams) are most marketing drugs than any other antibiotics. The β-lactams provide unlimited choices of biological activities, and they are efficaciously used as anticancer agent delivery systems directly to the tumor sites as pro-drugs. These records indicate that the designation and synthesis of new monobactams will be a favorable zone for improvement anticancer studying research.

Keywords    Monobactams, β-lactams, 2-Azetidinones, Anticancer

How to cite this article

Ahmed A. J. Mahmood (2022). Monobactams as anticancer: a review study. Science Archives, Vol. 3 (1), 1-10. http://dx.doi.org/10.47587/SA.2022.3101

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